The Human Upgrade: Biohacking for Longevity & Performance
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.
You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.
Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.
Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
- Update frequency
- every 3 days
- Average duration
- 57 minutes
- Episodes
- 1380
- Years Active
- 2011 - 2025
The Biohacking Tool That Will Change the World (Mitochondrial Transfusions) : 1304
This may be the most cutting-edge life extension technology you’ll hear about for decades. You’ll discover how mitochondrial transfusion, rejuvenation, and repair could reverse biological aging, supe…
00:54:24 |
Tue 22 Jul 2025
The Fastest-Acting Nootropic I’ve Ever Used : 1303
Host Dave Asprey uncovers how a groundbreaking topical glutathione spray bypasses IVs and pills to deliver rapid cellular upgrades for brain health, emotional resilience, and longevity.
00:46:00 |
Fri 18 Jul 2025
Why Big Pharma Hates Nitric Oxide (And How to Use It Anyway) : 1302
Host Dave Asprey joins nitric oxide expert Dr. Nathan Bryan to reveal how this overlooked molecule controls blood flow, metabolism, brain function, and sexual performance—and how to restore it for pe…
00:53:57 |
Thu 17 Jul 2025
Easy Oxygen Hacking for Mitochondria (The 15-Minute Upgrade) : 1301
A powerful conversation on how just 15 minutes of oxygen therapy can supercharge your mitochondria, reduce inflammation, and transform energy, brain function, and recovery.
00:49:51 |
Tue 15 Jul 2025
Facelifts, Breast Implants, and the REAL Fix for Wrinkles : 1300
Dave Asprey uncovers the real causes of wrinkles, the hidden risks of breast implants, and how stem cells, fat transfers, and advanced cosmetic procedures can regenerate your skin and optimize your b…
00:57:25 |
Thu 10 Jul 2025
Superintelligence, Transhumanism & Biohacking in 2027 : 1299
Host Dave Asprey and Soren Gordhamer explore how to stay emotionally and biologically resilient as AI, superintelligence, and transhumanism reshape human health and connection.
01:17:52 |
Tue 08 Jul 2025
Why I Add Creatine to My Coffee Every Morning (And You Should Too) : 1298
Creatine is one of the most powerful, science-backed supplements for brain optimization, mitochondria, and longevity—and in this episode, Dave Asprey reveals how to use it smarter for total human per…
00:30:41 |
Thu 03 Jul 2025
Death, Legacy & the Philosophy of Longevity — with Stephen Cave : 1297
Dave Asprey and Dr. Stephen Cave explore the philosophy, science, and ethical edge of longevity, revealing why the quest to live longer is as much about meaning and identity as it is about biohacking…
00:57:09 |
Tue 01 Jul 2025
Fix What’s Making You Feel Old—From Joints to Mitochondria | Dr. Greg Kelly : 1296
This episode uncovers the hidden causes of joint pain and premature aging—like insulin resistance, leaky gut, and mitochondrial dysfunction—and reveals how to restore mobility and longevity using sma…
00:45:39 |
Fri 27 Jun 2025
The Ultimate Guide to a Metabolism That Burns Fat Again — with Ben Azadi : 1295
Most people aren’t overweight because they eat too much—they’re metabolically stuck, and this episode shows you how to reset your fat-burning engine for good.
01:06:15 |
Thu 26 Jun 2025
Why Your Workouts Aren’t Giving You a Summer Body — with Nick Bare : 1294
A raw and insightful conversation with Nick Bare on building unbreakable discipline, training for longevity, and finding meaning through purposeful struggle.
00:49:23 |
Tue 24 Jun 2025
The Plants That Reverse Aging And Block Daily Toxins — with Darin Olien : 1293
Dave Asprey and Darin Olien expose the everyday toxins silently wrecking your biology, and reveal how rare plants, smarter detox strategies, and biohacking tools can reverse the damage and extend you…
01:05:01 |
Thu 19 Jun 2025
The Anti-Aging Skincare Trends That Are DAMAGING Your Skin | Amitay Eshel : 1292
Most anti-aging skincare is aging you faster—this episode reveals how to biohack your skin with NAD, spermidine, and red light to reverse senescence, repair the skin barrier, and unlock mitochondrial…
01:08:34 |
Tue 17 Jun 2025
Why Most Supplements Are a WASTE of Money (And What Actually Works) : 1291
Discover why most supplements fail, how to build a smarter stack with natural nootropics and adaptogens like saffron, GABA, and L-theanine, and how to boost energy, mood, and performance without caff…
00:43:21 |
Fri 13 Jun 2025
Can Injectable MDMA Become the Next Biohack in 2026? RFK Jr. vs FDA – Rick Doblin : 1290
Psychedelic science pioneer Rick Doblin joins Dave Asprey to reveal how MDMA-assisted therapy is transforming trauma healing, challenging the FDA, and reshaping the future of mental health and human …
00:53:28 |
Thu 12 Jun 2025
Should You Eat Dirt? The “Healthy” Foods Destroying Your Gut – Dr. Josh Axe : 1289
Modern food is making you sick—Host Dave Asprey and Dr. Josh Axe reveal how regenerative farming, biblical nutrition, and smarter supplementation can restore your gut, hormones, and longevity.
01:05:58 |
Tue 10 Jun 2025
How 5G Affects Brainwaves (and the New Science to Fix It) : 1288
Discover how minimalist movement, foot strength, and smarter walking routines can unlock peak performance, longevity, and full-body resilience.
00:52:54 |
Thu 05 Jun 2025
Mark Sisson: The Japanese Walking Hack That Outperforms 10,000 Steps A Day : 1287
Mark Sisson joins Dave Asprey to reveal why walking smarter—not more—is the ultimate biohack for longevity, performance, and total-body resilience.
01:22:37 |
Tue 03 Jun 2025
60 Days Alone in Antarctica: Amputation, Frostbite, and Lessons from Extreme Suffering | Akshay Nanavati : 1286
Akshay Nanavati returns to share how 60 days alone in Antarctica, dragging a 420-pound sled, became a radical experiment in pain, PTSD healing, spiritual transcendence, and the biology of human resil…
01:15:05 |
Thu 29 May 2025
10-Second Breath Hack to Reset Your Body & Mind | Aaron Alexander : 1285
Dave Asprey and Aaron Alexander reveal how breath, posture, and functional movement can instantly regulate your nervous system, boost energy, and unlock lasting resilience.
00:58:34 |
Tue 27 May 2025
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