The Human Upgrade: Biohacking for Longevity & Performance
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.
You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.
Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.
Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
- Update frequency
- every 3 days
- Average duration
- 57 minutes
- Episodes
- 1380
- Years Active
- 2011 - 2025
The Hidden Traps of “Healthy” Eating (Biohacking Daily Nutrition) : 1324
Dave Asprey and Max Lugavere explore sugar’s controversial role as both a performance enhancer and a metabolic disruptor, while unpacking how cooking methods, food quality, and kitchen literacy shape…
01:00:01 |
Fri 05 Sep 2025
Sulforaphane, Curcumin, and NEW GLP-1 Drugs (Biohacking for Longevity) : 1323
Two Johns Hopkins–trained researchers join Dave Asprey to uncover the hidden science of broccoli, revealing how sulforaphane and other plant compounds activate detox pathways, repair leaky gut, fuel …
01:02:41 |
Thu 04 Sep 2025
Mast Cells Explained: Biohacking Inflammation, Allergies, and Brain Fog : 1322
Johns Hopkins–trained physician Dr. Tania Dempsey joins Dave Asprey to reveal how Mast Cell Activation Syndrome connects mold, long COVID, autoimmunity, and brain inflammation—and the smarter biohack…
01:29:29 |
Tue 02 Sep 2025
What Is Uric Acid and How Does It Predict Your Longevity : 1321
Dr. David Perlmutter joins Host Dave Asprey to uncover how uric acid acts as a hidden metabolic switch—driving fat storage, disease risk, and longevity—and how simple biohacks like diet shifts, hydra…
01:09:44 |
Fri 29 Aug 2025
Hacking Dopamine Naturally: Pain, Focus, and Performance : 1320
Stanford psychiatrist Dr. Anna Lembke joins Host Dave Asprey to reveal how dopamine’s pleasure-pain balance drives addiction, motivation, and resilience—and how smarter not harder biohacks can reset …
01:15:10 |
Thu 28 Aug 2025
You Have A 25% Chance to Lose All Your Memory (Longevity Secrets) : 1319
Host Dave Asprey and neurologist Dr. Dale Bredesen uncover why Alzheimer’s is optional—and how biohacking, functional medicine, and early prevention can reverse cognitive decline and extend longevity…
01:46:41 |
Tue 26 Aug 2025
The Hormone War Dividing Female and Male Longevity : 1318
This episode explores how hormonal imbalance between men and women impacts longevity, perception, trust, and performance—through the lenses of biohacking, trauma, and spiritual neurobiology.
00:53:48 |
Fri 22 Aug 2025
The 10-Second At-Home Walk Test for Longevity (Easy Biohack) : 1317
Dr. Vonda Wright joins Host Dave Asprey to reveal how movement, muscle strength, and walking speed predict longevity—and how women can reclaim metabolic power through smarter not harder biohacks.
01:07:06 |
Thu 21 Aug 2025
PhD at MIT: The Longevity Molecule That Reverses Aging (250 Studies) : 1316
This episode of The Human Upgrade with Host Dave Asprey and MIT aging scientist Dr. Leonard Guarente uncovers how NAD, sirtuins, and cutting-edge supplements can slow biological aging, optimize mitoc…
01:08:04 |
Tue 19 Aug 2025
Still Fasting in 2025? Here’s How to Make It Work Better : 1315
This episode of The Human Upgrade reveals how to naturally activate your body’s stem cells to regenerate tissue, reverse aging, and supercharge recovery using cutting-edge biohacks like fasting, PEMF…
00:59:50 |
Fri 15 Aug 2025
How to Make Life-Changing Decisions Without Fear – Joe Hudson : 1314
This episode reveals the emotional formula that makes fasting easier and more effective by rewiring your subconscious patterns for healing, self-control, and longevity.
00:52:09 |
Thu 14 Aug 2025
The New Poisons Lurking Around You – Save Your Longevity : 1313
Host Dave Asprey and environmental health attorney Alan Bell expose the hidden poisons in everyday environments, reveal the top toxic chemicals destroying longevity and human performance, and share b…
00:58:58 |
Tue 12 Aug 2025
Jim Kwik: What I Take to Biohack Brain Speed and Focus : 1312
Jim Kwik joins Host Dave Asprey to reveal the exact nootropics, brain hacks, and biohacking routines he used to recover from traumatic brain injuries and unlock peak cognitive performance.
00:59:39 |
Fri 08 Aug 2025
Why I Inject a “Female Hormone” 3x a Week (Nootropic Hacking) : 1311
Dave Asprey joins Jay Campbell and Hunter Williams to explore cutting-edge peptides, hormone protocols, and bioregulators that enhance metabolism, optimize hormones, and reverse aging.
01:38:53 |
Thu 07 Aug 2025
Top 5 Dopamine Boosting Biohacks for Superhuman Energy : 1310
Dave Asprey and Lucas Aoun reveal the most advanced, underrated compounds for hacking dopamine, hormones, and mitochondria to radically upgrade motivation, focus, and resilience.
01:04:20 |
Tue 05 Aug 2025
Protein vs. Plants: The 50g-a-Meal Biohacking Rule : 1309
This episode of The Human Upgrade with Host Dave Asprey and Dr. Gabrielle Lyon reveals why eating 50 grams of high-quality animal protein per meal is the most overlooked biohacking strategy for rever…
00:47:04 |
Fri 01 Aug 2025
The Air Force Uses This Mind-Bending Sound Biohack — Try It Yourself! : 1308
This episode explores how the U.S. Air Force and elite performers are using personalized sound frequencies to rewire brainwaves, enhance neuroplasticity, and accelerate human performance—featuring Re…
00:54:05 |
Thu 31 Jul 2025
How To change ANY Habit In 63 Seconds (No Willpower Needed) : 1307
This episode reveals how to rewire your brain in 63 seconds using Dr. Caroline Leaf’s science-backed method for habit change, trauma healing, and mental self-regulation.
00:59:15 |
Tue 29 Jul 2025
Who Should Take Herbal Ecstasy Supplements? (The Billion-Dollar Backstory) : 1306
What is Herbal Ecstasy—and why does it matter? This might be one of the most insane episodes we’ve ever recorded, and we had to bring it back because the story is too wild, too relevant, and too pack…
00:59:12 |
Fri 25 Jul 2025
Boost Brain Power by 25% WITHOUT a Pill (Brain Optimization Secrets) : 1305
This episode reveals how your cultural programming shapes brain function, perception, and performance—and how decoding it can unlock next-level biohacking and longevity.
01:10:55 |
Thu 24 Jul 2025
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