Authentic Biochemistry
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
- Update frequency
- every day
- Average duration
- 37 minutes
- Episodes
- 998
- Years Active
- 2019 - 2025
Cell Cycle kinase inhibition may improve healthy cardiac aging while promoting global tumorigenesis. Authentic Biochemistry 10Feb2021 by Dr Guerra.
*Oncogenesis eventuates genetic mutation to epigenetic gene expression mechanisms with molecular signatures either inappropriately proscribed, incorrectly prescribed upon writing as dangerous and de…
Adipokine Update Lecture 2. Authentic Biochemistry Podcast. Dr. Dan Guerra Published 06 Feb 2021
Intra abdominal adiposity (IAA) linked obesity may be the most significant contributory factor to high mortality human disease after aging.
IAA presents with systemic and chronic inflammation and e…
Adipokine Mini Review I Daniel J. Guerra, PhD. 03 Feb 2021 Authentic Biochemistry Podcast Publications.
*Adipose tissue is the endocrine organ that secretes “adipokines”
*Nothing new to the Authentic Biochemistry crew; adipokines have been very well discussed here and their function as mediators of the…
Neuropeptide Y and the POMC neuronal antagonism in feeding behaviour maps onto fear conditioning. Dr. Dan Guerra 28 January 2021
Proceedings of The Nutrition Society.2012 71(4):521-33
Autophagy. 2009 May; 5(4): 558–560
Molecular and Cellular Endocrinology Volume 472, 5 September 2018, Pages 40-49
Int J Mol Sci. 2020 Nov; 21(21…
Neuropeptide Y and the fear conditioning response: are aging and obesity prodromal to anxiety and cognitive decline? Daniel J. Guerra PhD. Published 25 January 2021
Fear-conditioning learning is a low-threshold enduring psychiatric process that prepares a defense against dangerous phenomena and reduces the need to iteratively relearn the signal. It is a patt…
Corticotropin Releasing Factor and the Monoamine Fear Response in Aging. Sequence II. The reverse learning scenario as cognitive redistribution of neural transmission valency. DJGPhD.21.01.2021.
Homeostatic chronic low stress results in low to moderate levels of CRF in the LC in association with enhanced Extra-Dimensional Shifting and optimal executive decision making. However, acute or c…
The Corticotropin Releasing Factor and the Somatosensory Catecholamine Circuit in ExtraDimensional (attentional) Shifting. Dr Guerra 20 Jan 2021.AB.
Adaptation to stress-such as the fear response obtains dopaminergic input to striatum and prefrontal cortex and is thought to signal unexpected events and facilitate a shift in attention to promote …
Aging-associated SASP vs. MiDAS is a contrarion trade-off that may lead to neurodegeneration and autoinflammation vs tumorigenesis and heart disease respectively. Dr. Dan Guerra.17 Jan 2021. AB
The anti-inflammatory IL-10 pathway in the CNS can lead to Glioblastoma which is a disease presented 3-4 fold higher in people ≥65 years old, and with a mortality rate for the same age group some 7 f…
An Immunological Distinction between Senescence linked Secretory Phenotypes: SASP vs. Midas. Dr. Dan Guerra. Authentic Biochemistry 16 Jan 2021
Non-uniform ageing is a major associative risk factor for cancer and degenerative diseases and mitochondrial dysfunction is linked to cellular senescence in association with cell cycle arrest, telome…
The stress-induced Neural Network tracks Kantian Epistemology through characteristic action potential and neuromodulator/neurotransmitter phenomenology. Dr Guerra 13 JAN 2021.
LC axonal projections to the mPFC modulate a diversity of cognitive processes, including working memory, sustained attention, and flexible attention and under moderate rates of LC activity and NE rel…
Fear and Aging associated with neuronal conditioning and synaptogenesis via corticotropin releasing hormone. Dr. Dan Guerra; Authentic Biochemistry 13 JAN 2021
•Intensive and chronic or excessive stress diminishes intellectual performance and general cognition: this is a form of negative reinforcement and can be related to learning disability and anxiety ab…
Fear associated Corticotropin Releasing Factor and the Immune response are linked to CNS neutral Sphingomyelinase I. Dr Dan Guerra 09 January 2021
1. Corticotropin releasing factor (CRF) or hormone (CRH) is one of several neurohormones synthesized by specific hypothalamic nuclei in the brain and released into the portal system which bathes the …
Glycolysis is inhibited in T cells when Glucose 6 P non-competitively inhibits hexokinase after GLUT1 uptake of serum glucose:Setting the stage for lipogenesis.
Naïve T Cell metabolic regulationinvolves allosteric and kinetic mechanisms for maximum capacity to switch from glucose uptake to fatty acylCoA utilization for bioenergetic demand.
Multiple mechanism…
The Porosomal complex and complex lipid interconversions organizing the transport and secretion of cytokines after T cell Receptor Activation by APC's
There is a requirement of cholesterol and ceramides for the maintenance of neuronal and T cell porosome integrity, accompanying an interaction of phosphatidic acid (PA) and polyphosphoinositide (P…
Inhibitory PFK1 palmitoylation is facillitated by Acid Sphingomyelinase. Daniel J. Guerra, PhD. Authentic Biochemistry Podcast 02 January 2021
Cellular long chain acyl-CoA concentrations are controlled by multiple networked and coherent metabolic pathways ( including mitochondrial β-oxidation versus Golgi-ER-PL complex lipid synthesis vers…
T lymphocyte maturation and memory cell accumulation are differentially mediated by sphingomyelinase and protein palmitoylation. Dr Dan Guerra. 01 Jan 2021
Naive T lymphocytes, as opposed to memory T cells(which are more common in aging) carry out homolactate fermentitive glycolysis.
Memory cells are operating under complete aerobic metabolism involvi…
Tumor cells and T lymphocytes carry forward initially similar and subsequently distinct bioenergetic regulation through AMPK. Dr Guerra Authentic Biochemistry 30 Dec. 2020
Early stage TCR activated T cells with rampant lactic acid fermentation, fail to maintain adequate ATP levels , especially when glucose is limiting.This decrease in ATP relative to ADP+AMP results …
T cell metabolic Dialectics : deriving bioenergetic supremecy from glycolysis through fatty acid and lipid synthesis to ultimate fatty acid oxidation and ATP generation. Dr Daniel J. Guerra
Authentic Biochemistry Podcast 29 December 2020
Daniel J. Guerra Ph.D.
•All scientific inquiry should start with dialectical method that uses the current knowledge base to generate various specific …
On the Concept of Neuro-Correlation: A Theoretical Essay. Dr. Daniel J. Guerra . Authentic Biochemistry. 25 December 2020
Human neuroscientific research seeks to uncover patterns of commonality and uniformity to help define mechanisms which reliably result in the experience of thinking and interacting with the world. Th…
T Cell signal transduction involves kinase and transcription factor mediated expression of bioenergetic ensemble gene products. Dr DJ Guerra 23 December 2020
T cell agency initiates upon the stimulation of the TCR via presentation of cognate peptide-MHC complexes in associative ligand-mediated membrane co-receptor CD28 with co-stimulatory molecules presen…