Authentic Biochemistry
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
- Update frequency
- every day
- Average duration
- 37 minutes
- Episodes
- 996
- Years Active
- 2019 - 2025
Dr. Daniel Guerra presents Immuno Diaeventontological Framing of the Aging Human IV: SASP to cGAS via Melatonin
Dr. Guerra temporally organizes the lecture series toward the dialectical event by mindfully schematizing the SASP , the triad of DNA Damage Repair (DDR)responses, transcriptionally activated pro-i…
Dr. Guerra finds that the tumor-promoting and suppressing biochemical phenotypes of senescence are phenomenologically contrarion and thus physiologically compatible
Lipids, proteins carbohydrates and nucleotides-may function within an inflammatory and secretory modality. Thus, the SASP-Senescence-Associated Secretory Phenotype might deliver apoptosis, necropto…
Is cancer. or survival-achieving chemotherapy to treat early-onset tumorigenesis, linked to late in life senescence and human aging? The CD8+ T lymphocyte link.
A take-home message from this research may be that the immunosenescent phenotype in the elderly, while associated with an increased rate of infections and a diminished effect of vaccines, and increas…
Dr Guerra suggests targeting senescence as a means to alter the rate of aging is contrarion to healthy outcome because of derepression of tumorigenesis.
The human body is tempered by cellular fate paradigms that include senescence vs. proliferation during aging. A corruption in the senescnce associated secretory phenotype may be a proximal tareget to…
Senescence and Aging Relative to T lymphocytes may be linked to chemotherapy of testicular cancer and underlying cell cycle-CD transcriptional mutations.
Dr Guerra continues his associative pathobiochemical dialectic concerning T lymphocytte differentaition and senescence
The Th and Tc populations following uptake and processing of an antigen by an A…
Thymic involution-associated naive cd4+/cd8+ Tcell differentiation as observed in care-giver neuropsychological conditioning toward non-chronological immunosenescence.
Dr Guerra swings hard at Treg and naive CD4+/CD8+ lymphocytes in immunosenescence and the potential for infection with aging while accumulating T memory cell lineages confined to antigen./pathogen ex…
The teleology of Thymus mediated T regulatory cell clonal elimination and expansion via membrane associated receptor ligand interactions with innate and lymphocyte linneages. Dr Daniel J. GUERRA
1. Age -associated Immunosenescence is sometimes treated as synonymous with immune insufficiency, resulting in enhanced random infections and reduced vaccine immunity, and tumor surveillance
2. Self…
Dr Guerra presents: The Agency of the Immune System Treg Lymphocytes in Senescence and Human Aging. Authentic Biochemistry Podcast.14 September 2020
Cellular senescence is a physiological process with genetic determinants and external modififiersincluding stress, nutrition and cell fate reprogramming including autophagy and apoptosis.
Human aging…
Glucocorticoid Associated Naive Treg Differentiation and the Role of T Memory and Treg Sub-populations in Aging and End Stage Renal Disease
Dr Guerra discusses the Glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR) and its role in stabilizing T Regulatory cell populations relative to T memory cells and T effect…
Innate Like Lymphocyte and T Regulatory Cell Modulation against a backdrop of Immunostimulatory Effectors 01 September 2020.
Dr Guerra builds the foundation for transcription factor and epigenetic regulation of Treg cell differentiation in counterbalance to ILC's and T effector lymphocyte populations. Published 01 Septembe…
T lymphocyte and MVA pathway cross-talk in Breast Cancer, Lymphomas, Leukemias, CVD and aging. 24 August 2020
Dr. Daniel Guerra recombines the discussions of pharmacotherapeutic inhibition of prenylation in T cell activation and the failure of the NF-Kappa B pathway in estrogen receptor associated breast c…
The Sterol Response Element Binding Protein expression, cellular translocation and transcription factor pathways in T cell activation. 18 August 2020. by Dr Dan Guerra
Dr Guerra discusses the induction of transcription factor SREBP in activated T lymphocytes and the regulation of cellular translocation from the ER to the Golgi to the nucleus for the induction of p…
Dr Guerra lectures about Chronic Genomic Instability as a means to an end called senescence. Published 06 August 2020.
In this segment I discuss the phenomenon of DNA and genomic instability and the DNA repair systems implemented as mechanisms to drive cellular longevity . 06 August 2020 .
Dr Guerra discusses canonical Programmed Cell Death. Published 05 August 2020
Programmed Cell Death is a classical cell fate that occurs during embryonic development, tissue repair and both leucocyte and lymphocyte turnover. Various subforms of apoptosis ( classical, necroptos…
The Aging biochemical landscape as associated with chromatin organization and the alteration of cell cycle dynamics leading to the Senescence Associated Secretory Phenotype
Dr Guerra discusses the cancer marker gene mKI67 and its turnover linked to predisposition to euchromatin formation and the progression toward a senescent phenotype. Published 04 August 2020.
Dr Guerra discusses how Isoprenoid metabolism is linked to T cell activation via glycolysis and glutaminolysis. 02 August 2020
The mevalonic acid biosynthetic pathway maintains canonical cell activation triggers that link intermediary metabolism to T lymphocyte differentiation. 02 August 2020
Dr Guerra discusses the mTORC -AMPK axis and the control of the rate of aging as central to the slow growth hypothesis to longevity. 01 August 2020
The master regulator of protein translation, mTORC, is itself regulated by the stress-induced AMPK pathway. Rapamycin and semi-selective drugs regulating AMPK may reduce glioblastoma progression and…
Dr Guerra discusses aging associated oxidative phosphorylation, gluconeogenesis, NAD+ sirtuin activity and telomerase. 30 July 2020
In this lecture I gather some of the notable molecular components of age-related decline and the contrarion opposition imposed by cell proliferation. Published 30 July 2020. DJGPhD.
The Categorical Logic of Aging Systems as Influenced by Nutrition and the Introduction of Pharmacotherapeutics that Target Disease. Lecture VI. Published 27 July 2020.
Dr Dan Guerra examines nutritional restriction and exercise in combination with anti-diabetic drugs to impact the aging process. Published 27 July 2020.
The triad of biological auto-oxidation and the progress of aging as sine qua non to pathology. Published 26 July 2020.
Dr Guerra explains chain initiation, propagation and termination during lipid oxidation and the REDOX reactions of the electron transport chain as a lead in to enzymatic oxidations and the plastic…