Authentic Biochemistry
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
- Update frequency
- every day
- Average duration
- 37 minutes
- Episodes
- 996
- Years Active
- 2019 - 2025
Reactive oxygen is generated in biological systems leading to a physiological transit to senescence. Published 24 July 2020
Dr Guerra lays out the reduction of molecular oxygen to water and the accumulation of intermediate free radical oxygen species that are reduced via enzymatic activity and anti=oxidants. Aging is rela…
The oncogenic intermediary metabolic corruption as contrarion ontology to aging. Published 24 July 2020.
Dr Guerra explains how mutations in the glycolytic enzyme, pyruvate kinase, may lead to histone phosphorylation and the florid production of pro-oncogenic events. 24 July 2020.
Biochemical/Physiological Paradigms of Aging and Tumor Metabolism: the classical Warburg Aerobic Glycolysis and Krebs Cycle Corruption. 21 July 2020.
Dr. Guerra delivers lecture 2 on human aging with a walk on the other side of cell fate:-pathobiochemical immortalization during oncogenesis. Published 21 July 2020
Dr Guerra starts a series on the biochemistry and physiology of human aging and the ontology of sequential phenomenon in living systems. 19 July 2020.
Today I start this robust examination of human aging from the fundamentals of life span and the molecular events that mediate the rate of senescence. This is Part One.
Also please consider contributi…
Neutrophil Elastase and the extracellular trap mediated hyperinflammatory response leading to pulmonary edema, Na+ hyperabsorption: linkage to coronavirus .
The synthesis of protease-mediated hyper inflammation in pre-morbid respiratory distress pathobiochemical states linked to coronavirus transmission . How COPD and ARDS in association with cardiovascu…
Neutrophil elastase-mediated pulmonary disease including Cystic Fibrosis, RDS, COPD and viral pneumonia 10 July 2020
Airway passage disease has been well characterized in cystic fibrosis and this research which involves both clinical and animal model systems can inform general respiratory distress syndrome and vir…
A Narrative on the Nature of Belief as Universal within Knowledge yet Regularly Discounted in the Scientific World View. 09 July 2020
Dr Guerra presents his existential view on the purposive avoidance in science to admit the significance of belief in the knowledge paradigm. 09 July 2020.
Serpins and the Neutrophil Extracellular Traps in Respiratory Distress and the Coronavirus. 08 July 2020
Dr Guerra recaps protease mechanisms and zymogen activation ultimately linking serpin mediation of neutrophil elastase during coronavirus infection. Published 08 July 2020
Dr Guerra examines proteases and protease inhibitors in ovarian and hepatocellular cancers and their pathobiochemical mechanisms. 03 July 2020.
Dr Guerra presents how a protease inhibitor protects a serine protease that is linked to ovarian cancer progression plus how protease inhibitor polymerization overloads the Endoplasmic Reticulum Asso…
The Role of Alpha anti-trypsin in the IL-1 pro-inflammatory cascade. 30 June 2020
Far from becoming monomeric and unimodal in effect, the anti-trypsin protease inhibitor functions to modulate the transcriptome and proteome of induced pro-inflammatory responses in both systemic and…
SERPINs and the Acute Phase Response in the Pathophysiological State. Dr Dan Guerra, 29 June 2020
Dr Guerra targets his lecture on protease inhibitors as positive acute phase proteins serving a modality of repression against proteolytic degradation processes as induced by the pro-inflammatory cyt…
Dr Guerra Presents: Serine Protease Inhibitor Biochemistry in Human Health and Disease I. 25 June 2020
In this session Dr Guerra discusses the physiological and pathophysiological roles of serine protease inhibitors (SERPINS). For example, the physiological role of plasminogen activator inhibitor 1 …
Dialectical Event Ontological Analysis of the Scientific Method as Prolegomena to a Recap of PEDF in Hepatocellular Carcinoma
In this Lecture I define and then implement a dialectical approach to biomedical scientific research methods that involves event ontologies relative to a non-paradoxical understanding of cancer path…
Dr. Guerra presents: Contrarion opposition of PEDF in Tumor progression explained via dyslipidaemia and corruption of AMPK mediated control. 12 June 2020.
Dr. Dan Guerra apprehends several research publications going back to 2012 and proceeding through 2019 in a synthesis of oppostional logic and the published scientific evidence to explain the mediat…
Dr Guerra's second lecture on T2D and its link to Obesity plus a bonus Clinical Misdiagnosis Study Question Review. 31 May 2020
A brief concluding lecture on the linkage of obesity with Type 2 diabetes plus a clinical case study discussion and review question of a mis-diagnosis via anchoring.
Dr Guerra discusses Obesity-linked Type 2 Diabetes and clinical manifestation of the disease
Dr Guerra lays out the prodromal manifestations of metabolic syndrome and insulin resitance that can lead to Type 2 diabetes in the obese sedentary aging population.
Nutritional biochemistry and the obesogenic induction of insulin resistance and type-2 diabetes. Dr Daniel J. Guerra. 25 May 2020
Dr Guerra lays down the basics of bioenergetics and the roles of carbohydrate and lipid metabolism in the obese state leading to type 2 diabetes and the pathophysiological sequalae in chronic disease…
Obesity and pathophysiological Implications including hyper-Immunity, increased susceptibility to serious infection and high-mortality disease.
Dr Guerra reminds his audience that obesity is the global health pandemic of a generation and that it leads to multiple high mortality diseases associated with a corruption in lipid metabolism, both …
Basic Endocrine Hormone Nomenclature and physiological biochemistry. Authentic Biochemistry 14 May 2020.
Dr Guerra provides the basic detail necessary to prepare one for our future examination of the current peer-reviewed literature involving hormonal control over health , infection and inflammation via…
General Hormone Lectures II. The Hypothalamic Pituitary Axis. Dr Daniel Guerra. 05 May 2020.
Dr Guerra discusses hormonal ontology via receptor -binding mechanisms plus the cascade of the hypothalamic-pituitary axis.