Authentic Biochemistry

Single-nucleotide polymorphisms and  copy-number variations (CNV’s)  result from genome wide chromosomal abnormalities including large deletions and duplications where the the immune system appears t…

Neuroinflammatory mediators play a critical role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery …

An Introduction to the theory of immunoepigenetic tailoring of human instanence.

Dr. Guerra

Authentic Biochemistry Podcast Studios

J Immunol August 1, 2017, 199 (3) 874-884

Ann Rev Cell Dev Biol 2018. 34:111-136

Blood. 2016 Apr 14;127(15):1930-9

J BiolChem. 2017 Aug 25; 292(34): 14292–14307

What is involved to make a sound decision?

Biochemistry is a scientific discipline; one that examines and interprets the foundational structures and functions of living systems.

As with any judgment,…

Annual Review of Cell and Developmental Biology Vol. 34:111-136

Journal of Neuroscience 23 October 2019, 39 (43) 8576-8583

Archivum Immunologiae et Therapiae Experimentalis 2013 Apr;61(2):119-25.

Electron transport and the anapleurotics of intermediary metabolism. Dr. Daniel J. Guerra

Authentic Biochemistry Studios

21.3.21

•Impaired immunological responsiveness is common in the elderly

•The immunological competence of an individual is determined by the presence of mature lymphocytes formed in primary lymphoid organs, a…

•Cytokines regulate the intensity and duration of the immune response, and  they can act as growth factors or stimulants or even inhibitors of T cell amplification and differentiation.

•Cytokines are…

1. Glucokinase- GK is in the neuron

2.Control over glycolysis via GK mediates neural transmission

3.  Neuronal GK further functions on  the appetite/satiety axis thus partially regulating the HPA axi…

If  γ-aminobutyric acid (GABA) concentration drops significantly in the synaptic cleft, excitotoxicity can obtain, sometimes presenting with epileptic convulsions.This can be reversed by decreasing t…

A basic lecture on reactive oxygen synthesis and reduction coupled with glutathione, folic acid and amino acid metabolism.

This lecture is foundational for subsequent synthesis with neural transmissi…

CPS-1 activity is regulated by liver enriched transcription factors as well as Sirtuin-mediated de-acylation.

Glutaminase breaks down glutamine into glutamate and ammonia. Glutamate also yields addi…

Glutaminase breaks down glutamine into glutamate and ammonia. Glutamate also yields additional urea via the enzyme glutamate dehydrogenase. From here, ammonia is initially incorporated into hepatocyt…

SIRT5 causes deglutarylation and functional activation of glutamate dehydrogenase 1  which is  essential to cellular glutaminolysis.Indeed, SIRT5 supports the anaplerotic transamination entry of glut…

The Pyruvate dehydrogenase hydrated E1-E2 interface is  enthalpy driven, while the dehydrated  E3-peripheral subunit binding domain complex is driven by entropy obtaining a favourable  delta G= delta…

•Free energy change(chemical potential difference) for transporting 1 mole of a substance from region where its concentration is C1 (e.g., Cout) to region where its concentration is C2 (e.g., Cin):

∆…

Mini Lecture 1 on Membrane Physiological Biochemistry.

The amino acid sequence of membrane associated polypeptides obtains secondary structure, glycosylation, acylation and hydropathy which confer fu…

For Valentine's Day Eve. A bouquet assortment of  biochemical  thermodynamic principles and  metaphysical event ontologies.

To finish my thoughts:

 Is life necessary? How to answer this question? One…