Authentic Biochemistry
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
- Update frequency
- every day
- Average duration
- 37 minutes
- Episodes
- 998
- Years Active
- 2019 - 2025
Amino acid metabolism I: An initial primer for subsequent discussions in Aging. Dr Guerra. 07July2021. Authentic Biochemistry.
This is one of my classical biochemistry introductory lectures on amino acid utilization.
Mesenchymal stem cell fate and the mediation of age-associated senescence or plasticity in the elderly via immune response valency. DJGPhD 03 July 2021
Trends in Immunology Volume 36, Issue 4, 2015, 217–228
Carcinogenesis 2015;36:1180-1192
Detailing the Senescent to Mesenchymal Transition in Aging : Links to Cancer vs. Apoptosis. DJGPhD 28 June 2021.
Clinical and Molecular Allergy volume 15, Article number: 21 (2017)
Front. Immunol., 25 September 2019 | https://doi.org/10.3389/fimmu.2019.02247
Genomic damage, DDR, and the roles of inflammation and DNA epigenetic retailoring in the senescent phenotype. DJGPhD 24.6.21
Oncotarget. 2013 Oct; 4(10): 1552–1553
Pharmacodynamics: General Considerations and Clinical Trials. Dr. Dan Guerra. Authentic Biochemistry 12 June 2021
In this episode Dr. Guerra provides the overview of Pharmacodynamics .
Pharmacokinetics Synoptic with an Introduction to Aging Phenomena. Dr Daniel J. Guerra. 09June2021 authentic Biochemistry.
A.D.M.E.
Anesthesiology Clinics, 2019-09-01, Volume 37, Issue 3, Pages 475-492.
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Cardiovascular disease risk and malnutrition are associated with aging morbidity and obesity. Dr. Guerra. 8 June 2021. Authentic Biochemistry
Risk factors for aging morbidity are linked to large variations in protein synthesis and lack of adipose derived TAG utilization.
The immune response becomes compromised during aging leading to stat…
Ceramide mediated pathophysiology of aging-associated neurodegeneration. Dr. Dan Guerra. Authentic Biochemistry.05 June 2021.
Seminars in Cell & Developmental Biology Volume 40, April 2015, Pages 115-126
Pharmaceutical Research March 2018, 35:49
Journal of Molecular Endocrinology 2017. 58, 1; 10.1530/JME-16-0182
J. Lipid Re…
Immuno Endocrine Regulation of Metabolism May-June 2021. Dr. Dan Guerra Authentic Biochemistry.
Feng, T., Yang, X., Hao, S. et al. Immunol Res. 05 April 2020
Molecular Neurodegeneration volume 7, Article number: 45 (2012)
J Biol Chem. 2019 Jun 7;294(23):9213-9224
Aging and Cancer Via Immunosenescence and Pro-inflammatory Cytokines: Relative loss of Naive T cell Populations in the Elderly. DJGPhD. 26 March 2021
Annu. Rev. Physiol. 2013. 75:685–705
Nutrients. 2020 Mar; 12(3): 622
Pathobiochemical linkages between Alzheimer's Disease and Autism Spectrum Disorders: Associative Molecular Patterns with Diverse Pathologies. DJGPhD. 18 May 2021
FASEB J. 2013 Jun; 27(6): 2458–2467.
Scientific Reports volume 7, Article number: 13763 (2017)
Immunomodulatory effects on neuropsychiatric states: classic rodent model studies. Dr. Guerra. 17.5.21 Authentic Biochemistry
Scientific Reports volume 9, Article number: 1220 (2019)
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Oct 12
Bulletin of Experimental Biology and Medicine.2003. 136.(3). 1573-8221
Pharmacological…
Linking TLR's with the VTA and NE circuitry: Immune mediated neurodegeneration and neuroprotection in the balance. DJGPhD 16 May 2021
Brain Behav Immun. 2019 Oct;81:41-51
Neuroimmunomodulation 2002/2003;10:101-121
Front. Neurol., 23 January 2018
Microglial TLR activation mediates Aging-Associated CNS Neurodegeneration. Dr. Daniel Guerra. Authentic Biochemistry Podcast. 13 May 2021.
TLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling.
TLR interactions from CNS-resident microglia can obtain …
The Innate Immune Response Instantiates the Pattern for future Inflammatory Prodromal Neurodegeneration. DJGPhD. 08May 2021
Pathogens, and abiotic ischaemic damage manifest a constellation of molecular interactions triggering pattern recognition receptors such as TLR's, with canonical protein binding domains that signal …
Pattern Recognition Receptors: Some molecular detail. DJGPhD Authentic Biochemistry. 07 May 2021
Oncotarget. 2016 Jan 26; 7(4): 4195–4209
Nature Reviews Immunology volume 6, pages644–658(2006)
Ischemic Infarct as a model for immune mediated CNS regeneration or degeneration via microglial stimulation. Dr. Daniel J Guerra. Authentic Biochemistry . 06May2021
The removal of damaged neurons and associated synaptic connections with the
simultaneous repair of other neuronal circuits is a mechanism for the sculpting of
the brain network and thus a means by wh…
Lymphocyte and Resident Microglia participate in CNS formation, Epigenetic Modifications and Neurodegeneration via RAG-Recombinase. Authentic Biochemistry Podcast by DJGPhD. 27 April 2021
Authentic Biochemistry Podcast 27 April 2021
References
Clin Diagn Lab Immunol. 2003 Jan;10(1):13-8
J Exp Med (2012) 209 (1): 187–199.
Cell Reports 2020. V 30, (Issue 5) :1585-1597.e6
The RAG Recombinase Interacts with T lymphocyte Programmed Cell Death Loci. Dr Dan Guerra Authentic Biochemistry Podcast 26 April 2021
References
Experimental & Molecular Medicine volume51, Article number: 80 (2019)
Am J Nephrol.2017;46(5):371-379
EMBO Rep . 2003 Aug;4(8):774-80
J Biol Chem. 2020 Jul 3;295(27):9052-9060
Mol Immuno…
Dr. Guerra presents: The CNS and the Immune System are linked to Recombination and the Epigenome. Lecture IV. 24.4.21 Authentic Biochemistry
As an hypothetico-deduction, Dr. Guerra proposes that the Recombination Activating Gene-RAG System is a Potential Candidate in Age Associated Morbidity.
In conjunction with a neutral sphingomyelinas…