Authentic Biochemistry
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
- Update frequency
- every day
- Average duration
- 37 minutes
- Episodes
- 998
- Years Active
- 2019 - 2025
Bio-Molecular Regulator Series . AMPK. Part One. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Production.19.12.21.
An introductory lecture on the biomolecular sensor kinase, Adenosyl Mono-Phosphate (protein) Kinase; AMPK.
References
Mol Genet Metab. 2013 Jul;109(3):260-8
PLoS One. 2016 Aug 16;11(8):e0161252.
Exp…
T-lymphocyte and macrophage membrane CD38 ecto-enzyme mediated NAD catabolism is associated with ageing and the decline in Sirtuin-mediated deacylase activity. DJGPhD.11.Dec.21' Authentic Biochemistry
References
Cell Metabolism. 2016. 23, 1127–1139
Cells 2020, 9(1), 228
Front. Immunol., 31 May 2019
Int J Mol Sci. 2020 Nov; 21(22): 8609
Circ Res. 2018 Sep 14; 123(7): 868–885.
Int J Mol Sci. 2019 Ma…
Aposteriori synthesis of neuroendocrine linked clock chronicity and the Senescent associated Secretory Phenotype through the synthetic apriori lens of NAD+. DJGPhD.10Dec21. Authentic Biochemistry
References
Nat Cell Biol. 2019 Mar; 21(3): 397–407
J Diabetes Metab Disord. 2020 Jul 21;19(2):1797-1825
Int. J. Mol. Sci. 2014, 15, 16848-16884
How testosterone-aromatase derived estradiol transformation to 2-methoxy-17beta-estradiol can mitigate cell proliferation by promoting a senescent phenotype.DJGPhD. Authentic Biochemistry.8.DEC.21
Besides 2-methoxy-17beta-estradiol, cell cycle arrest via chromatin deacetylation can mitigate cell proliferation by decreasing global transcription while promoting the expression of tumor suppresso…
Blocking cellular senescence may suppress autoimmune diseases and reactive oxygen mediated cell death but non-ironically promote oncogenesis and tumor development during ageing. DJGPhD. 06.DEC.21
Cell fate from Either ageing associated senescence to programmed cell death OR cell proliferation is finely tuned to the splice variant expression of Cell Cycle dependent kinase inhibitors and the r…
Ageing and Asymmetric Dimethylarginine (ADMA)in Endothelial Nitric Oxide Synthase inhibition-associated decrease in respiratory vasodilation. Dr Dan Guerra 24.11.21 Authentic Biochemistry
Age Ageing, Volume 48, Issue 6, November 2019, Pages 776–782
Biomedicines. 2020 Aug 6;8(8):277
Closing the window and drawing the curtain: cancer phenotypes are resolute signatures of Immunosenescence and inflammaging induced epigenetic collapse of vital biochemical homeostasis. DJGPhD.20/11/21
Dr. Guerra authentically arrives at the inveighing cancer paradigm contribution to the sickness unto death.
Sealing Fate: Immunosenescent and inflammatory mechanisms combine the ineffectual with the increscent pathophysiology of sickness unto death. DJGPhD. 17.11.21
Nutrients. 2020 Mar; 12(3): 622.
Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43.The Immune System and Its Dysregulation with Aging
Ludmila Müller, Svetlana Di Bened…
The interplay between Immunosenescence and inflammaging conduct the innate and acquired immune response toward functional cellular rigidity and incompetence obtaining morbidity and mortality. DJGPhD.
1.Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43. The Immune System and Its Dysregulation with Aging. Ludmila Müller, Svetlana Di Benedetto, and Graham Pawelec. Sp…
Fine detail of Treg cell control over inflammation suppression via FoxP3 transcriptional modulation. Aging and Obesity will limit this control leading to hyperinflammation. DJGPhD. 08Nov2021
References
Front. Immunol., 29 June 2012
J Immunol 2016;197:3762-3770
Front. Immunol., 03 February 2020
T cell receptor signaling kinase dynamics after APC activation. Co-activating CD28 becomes deficient via immunosenescence thus corrupting T cell efficiency in the elderly. 26.10.2021 DJGPhD.
The Src-family kinase Lck regulates T-cell development, activation, proliferation, and immune synapse dynamics. These are the initiation phases of TCR signaling. Upon antigen presentation via the AP…
Indeed oxysterol LDL , circulating hepatic-derived convertase, T lymphocyte differentiation and macrophage to foam cell degeneration obtain the aging cardiovascular/pulmonary pathophysiological state.
Dr Guerra carries out the synthesis of multiple pathobiochemical events into an architechtonic of the aging human co-morbidity resulting in a sickness unto death.
Authentic Biochemistry Production
2…
How Oxysterol LDL associates with macrophage and T lymphocyte infiltration during aging to generate the hyperinflammatory atherosclerotic plaque. DJGPhD. 19.10.21. Authentic Biochemistry.
That there are senescence-associated decreases in the JAK-STAT signaling transduction cascade has been observed in human lymphocyte lineages. This phenomena, as associated with a decreased JAK- tyr…
Aging results in corruption of T lymphocyte differentiation associated with chromatin instability and epithelial to mesenchymal transitions leading to the pre-cancerous state. DJGPhD 16.10.21
Chromatin instability leads to alterations in gene expression that re-directs cellular senescence by corruption of chemokine and cytokine signalling resulting in epithelial to mesenchymal transitions…
Lymphocyte maturation and the special Innate like Lymphocyte Subclass including Natural Killer and other ILC lineages. DJGPhD.14.10.21. Authentic Biochemistry
Front Cell Dev Biol. 2019; 7: 226
Advances in Immunology. 2011 v.109.Pp125
Cell Reports 10, 2043–2054, March 31, 2015
Experimental & Molecular Medicine volume 51, pages1–15 (2019)
Immunosenescence and Inflammaging via thymic Involution and comorbid pathophysiology of obesity and aging present a chronic inflammatory phenotype prone to morbidity. DJGPhD. Oct.04,2021. Authentic BC
Dr. Guerra details the aging immune phenotype at the transcriptional and metabolic level.
References
Immun Ageing. 2020; 17: 2.
Experimental & Molecular Medicine volume 51, Article number: 80 (2019)
…
Natural cytotoxicity receptors (NCR's) within group 3 innate lymphoid cells (ILC3): an association of transcription factors in IBD's and aging. DJGPhD. 03.10.21 Authentic Biochemistry.
ILC3 can contribute to the progression and aggravation of IBD's while both IL-22 and IL-17, along with IFN-γ, are overexpressed by the dysregulation of NCR− ILC3 or NCR+ ILC3 function
NCR (natural cy…
Omega three fatty acids and PE N-methyl transferase are associated with methylation and acetylation patterning in NK cells via AMPK and stress.DJGPhD. 29 September 2021.
Omega-Three VLCPUFA's as asymmetrically distributed in membrane glycerolphospholipids mediate vesiculation and permeability of endothelia to circulating lymphocytes and leukocytes thus coupling folic…
Natural Killer Cell switching via demethylation of Histone 3 LYS may correlate with the human aging phenotypic hyper-inflammatory state. DJGPhD. 28.9.21
Pro-inflammatory gene transcription is tanked when demethylation is inhibited but cytotoxicity of virally infected or cancer cells by NK’s (where demethylation is inhibited) remains intact.
Referenc…
The Genome and the Immunoepigenome interact across a three-way trigonal planar field with the Environment to Obtain the Aging Phenomena. DJGPhD.27.9.21
Dr. Guerra discusses some of the complexity of both the epigenetic mechanisms and cellular responses associated with immunomodulatory failure in the aging human.
References
Anal Cell Pathol (Amst).…