Base by Base

️ Episode 50: The Microbiome for Clinicians — Bridging Research and Practice

In this episode of Base by Base, we explore a Perspective article by Porcari et al. (2025) in Cell titled “The microbiome …

️ Episode 49: Chitin as a Reservoir for Horizontal Gene Transfer — Environmental DNA Adsorption and Natural Transformation in Vibrio cholerae

In this episode of Base by Base, we explore the study by …

️ Episode 48: Mainstreaming Genetic Testing — A Conceptual Framework for Expanding Genomic Medicine

In this episode of Base by Base, we explore an important policy and practice shift presented by Mac…

️ Episode 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network
In this episode of Base by Base, we explore a systems-level framework unveiled by Kleist et al. (2025) in Cell, w…

️ Episode 46: Pan-Epitranscriptomic Control — How tRNA and m6A Interact to Regulate mRNA Decay

In this episode of Base by Base, we delve into a landmark study by Linder et al. (2025), published in Ce…

️ Episode 45: Probing Nucleolar Mechanics — RNA-Dependent Viscoelasticity of Nucleolar Subcompartments

In this episode of Base por Base, we delve into a groundbreaking study by Cheng et al. (2025) in…

️ Episode 44: Proofreading Precision — Unveiling the Cryo-EM Mechanism of Human DNA Polymerase ε Holoenzyme

In this episode of Base per Base, we delve into a groundbreaking study by Wang et al. (2025…

️ Episode 43: Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes

In this episode of Base by Base, we explore the groundbreaking work by Kjærgaard et al. (2025) in Cell, where…

️ Episode 42: Amino Acids Catalyse RNA Formation — Unlocking Prebiotic Cross-Catalysis

In this episode of Base por Base, we delve into the groundbreaking 2025 Nature Communications study by Rout et a…

️ Episode 41: Public Preferences for Genomic Newborn Screening in Australia — Insights from Discrete Choice Experiments
In this episode of Base by Base, we discuss a landmark study by Peters et al. (…

️ Episode 40: Lysosomal Proton Leak — Uncovering SLC7A11’s Role as an Unconventional H⁺ Transit Pathway

In this episode of Base by Base, we delve into a revealing study by Zhou et al. (2025) in Cell …

️ Episode 39: Whole-Genome Polygenic Score Inference — Fast and Memory-Efficient Algorithms for Scalable PRS

In this episode of Base by Base, we dive into the methodological breakthroughs of Zabad et…

️ Episode 38: The Recency and Geographical Origins of Bat Viruses Ancestral to SARS-CoV and SARS-CoV-2
In this episode of Base by Base, we delve into a landmark study by Pekar et al. (2025) in Cell t…

️ Episode 37: Proteomic Clues — Prioritizing Functional Missense Variants with Chemoproteomics

In this episode of Base by Base, we highlight a new study by Palafox et al. (2025) in The American Journ…

️ Episode 36: Bi-allelic POPDC2 Variants: A Novel Autosomal Recessive Cardiac Syndrome
In this episode of Base by Base, we discuss a groundbreaking study by Nicastro et al. (2025) published in The Am…

️ Episode 35: Tracing the Evolutionary History of CCR5Δ32 — Insights from Ancient and Modern Genomes
In this episode of Base by Base, we explore groundbreaking research by Ravn et al. (2025) publishe…

️ Episode 34: Enzyme Replacement Therapy in Homocystinuria — Safety and Efficacy of Pegtibatinase in the Phase 1/2 COMPOSE Trial
In this episode of Base by Base, we delve into early findings from Fic…

️ Episode 33: Mis-splicing-derived Neoantigens — A New Avenue for Immunotherapy in Leukemia

In this episode of Base por Base, we examine groundbreaking research by Kim et al. (2025), recently publish…

️ Episode 32: Idursulfase Beta — A New Therapeutic Option for MPS II with Strong Clinical Evidence
In this episode of Base por Base, we delve into a pivotal phase 3 clinical study published by Sohn e…

️ Episode 31: Decoding Hidden Signals — Genome Sequencing Reveals Cryptic Splicing Variants in Marfan Syndrome

In this episode of Base por Base, we delve into a breakthrough study by Walker et al. (2…