Base by Base

️ Episode 70: Scalable Screening of Ternary-Code DNA Methylation Dynamics Associated with Human Traits

In this episode of Base por Base, we delve into a methodological breakthrough reported by Goldbe…

️ Episode 69: Synthetic Dosage Lethality of PLK1 — Targetable Vulnerabilities in PLK1-Overexpressing Cancers
In this episode of Base por Base, we delve into a comprehensive study by Cunningham et al.…

️ Episode 67: Smarter Signals — How Multimodal AI Boosts Genetic Prediction of Heart Disease

In this episode of Base por Base, we delve into a major advancement in the intersection of artificial inte…

️ Episode 66: Mainstreaming Clinical Genetic Testing — A Conceptual Framework

In this episode of Base por Base, we delve into the consensus-based framework introduced by Mackley et al. (2025) in Gene…

️ Episode 65: Uncovering Hidden Splice Defects — Genome Sequencing and Group-Enrichment in Marfan Syndrome

In this episode of Base por Base, we delve into a groundbreaking study by Walker et al. (202…

️ Episode 64: Pisces — A Multi-Modal Framework for Predicting Drug Combination Synergy

In this episode of Base by Base, we delve into a groundbreaking methodological advance published by Xu et al. (2…

️ Episode 63: Sampling Scale Matters — A Spatial Model for Rare Variant Discovery in Biobank-Scale Datasets

In this episode of Base by Base, we delve into a methodological advance by Steiner et al. (…

️ Episode 62: Breaking Resistance — How BRCA2-Deficient Tumors Escape PARP Inhibition Without Reversion Mutations
In this episode of Base by Base, we explore a study by Pappas et al. (2025), publishe…

️ Episode 60: Epi-PRS — A New Frontier in Polygenic Risk Prediction with Epigenomic Features
In this episode of Base by Base, we explore a breakthrough in genetic risk modeling presented by Zeng et a…

️ Episode 59: Building Trust — Redefining Participant and Community Engagement in Cancer Genomics
In this episode of Base by Base, we dive into a landmark article by Crossnohere et al. (2025), soon t…

️ Episode 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity

In this episode of Base by Base, we explore a groundbreaking study by Fusari et al. (2025), published…

️ Episode 57: Low Uptake of Genetic Testing in Medicaid-Enrolled Children with ASD and Intellectual Disability

In this episode of Base by Base, we delve into a comprehensive analysis by Brown et al. …

️ Episode 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis

In this episode of Base by Base, we examine the transformative findings of Woo et…

️ Episode 55: Denisovan DNA in Dental Calculus — Linking Morphology and Genetics in a 146,000-Year-Old Hominin

In this episode of Base by Base, we delve into a groundbreaking study by Fu et al. (2025…

️ Episode 54: Temporal Immune Landscapes — A Multi-Omic Lens on COVID-19 in End-Stage Kidney Disease

In this new Base by Base episode we unpack a 2025 Cell Genomics study by Stephenson et al. that fo…

️ Episode 53: Weighing the Evidence — A Systematic Review of Polygenic Risk Score Economic Evaluations
In this episode of Base by Base, we explore the systematic review by Siena et al. (2025) in The …

️ Episode 51: Diagnosing the Undiagnosed — A Phenotype-Driven Pipeline for Mitochondrial DNA Discovery

In this episode of Base by Base, we dive into a powerful phenotype-guided strategy to uncover mi…