Base by Base

️ Episode 110: Whole-exome sequencing identifies new schizophrenia risk genes

In this episode of PaperCast Base by Base, we explore a landmark whole-exome sequencing study that expands our understan…

️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality

In this episode of PaperCast Base by Base, we explore how loss of the RNA editor ADAR1 becomes lethal to BRCA1/2‑mutant …

️ Episode 108: Epigenome Editing Reverses HBG Silencing

In this episode of PaperCast Base by Base, we explore how targeted removal of CpG methylation at the HBG promoters causally reactivates fetal …

Episode 107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases

In this episode of PaperCast Base by Base, we explore a large-scale genome-wide association study invest…

️ Episode 106: Decoding Brain Maps for Pharmacotranscriptomics

In this episode of PaperCast Base by Base, we explore a Nature Communications study, that introduces a fast, surface-based framework t…

️ Episode 105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance

In this episode of PaperCast Base by Base, we explore groundbreaking research revealing how the evolutionary …

Episode 104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation

In this episode of PaperCast Base by Base, we explore a large cross-ancestry st…

️ Episode 103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery

In this episode of PaperCast Base by Base, we explore how large-scale exome sequencing combined with explainable …

Episode 102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

In this episode of PaperCast Base by Base, we explore how large-scale pharmacogenomics translates to real-world…

️Episode 101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis

In this episode of PaperCast Base by Base, we explore how JAK2 inhibition with ruxolitinib can reshape clonal architecture in …

️ Episode 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia

In this episode of PaperCast Base by Base, we explore a groundbreaking study that maps the epigenomic landscape of Acute My…

️ Episode 99: NXT2: A Testis-Specific RNA Export Factor Essential for Spermatogenesis

In this episode of PaperCast Base by Base, we explore how the testis-enriched paralog NXT2 orchestrates nucleocyt…

️ Episode 98: Cell Marker Accordion: Interpretable Single-Cell and Spatial Omics Annotation in Health and Disease

In this episode of PaperCast Base by Base, we explore a user-friendly platform develo…

️ Episode 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial

In this episode of PaperCast Base by Base, we explore how integrated whole genome and transcriptome sequencing uncovers clini…

️ Episode 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease

In this episode of PaperCast Base by Base, we explore a large-scale proteomic study comparing cerebr…

️ Episode 95: Mitochondria on the Move: Biotechnological Strategies for Transfer and Transplantation

In this episode of PaperCast Base by Base, we explore recent advances in biotechnological methods …

️ Episode 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer

In this episode of PaperCast Base by Base, we explore how integrated DNA methylation, RNA sequencing, and histone mo…

️ Episode 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13

In this episode of PaperCast Base by Base, we explore how a bovine-derived H5N1 virus from clade 2.3.4.4b gen…

️ Episode 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration

In this episode of PaperCast Base by Base, we explore a genome‑wide association and fine‑mapping study i…

️ Episode 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins

In this episode of PaperCast Base by Base, we explore a large-scale genome-wide…