This Week in Neuroscience

Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, whic…

TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory.

Hosts: Vincent Racaniello, …

TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum.

Hosts: Vince…

While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods…

On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its funct…

Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders.

Ho…

Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful ba…

Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racanie…

Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzhei…

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

Hosts: Ori…

Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.

Hosts: Ori Lieberman, Andres Bendesky, and Vincent Ra…

TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.

Hosts: Ori Lieberman, Andres Bendesky…

Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.

Hosts: Ori Liebe…

TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.

Hosts: Ori Lieberman, Erin Cali…

The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses.

Hosts: Ori Lieberman, Jason Shepherd,  Erin Calipari and Vincent Racanie…

Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes.

Hosts: Ori Lieberman, Andres Bendesky, andJason Shepherd

Gues…

Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19.

Hosts: Ori…

Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons.

Hosts: Andres Bendesky, Jason Shepherd, and Vincent…

Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction.

Hosts: Ori L…