This Week in Microbiology

TWiM explains how magnesium modulates cell division frequency of a soil bacillus, and killing of fungi by Acinetobacter baumannii via a Type VI DNase Effector.

Hosts: Vincent Racaniello, Michael Sch…

TWiM describes successful phage therapy against a mycobacterial lung infection, and how encapsulation of the cell wall protects S. pneumoniae from its major peptidoglycan hydrolase and host defenses.

TWiM explores the relationship between the gut microbiome and depressive symptoms, and how purine nucleotides act as adjuvants to antibiotics.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele …

On this episode of TWiM, we reveal widespread stop-codon recoding in bacteriophages that may regulate translation of lytic genes, and how Staphylococcus aureus inhibits Pseudomonas aeruginosa growth.

TWiM presents evidence that over half of human pathogenic diseases are impacted by climate change, and considers how a novel prokaryote discovered next to an underground stream illuminates the pathwa…

TWiM reveals high rates of co-transformation of plasmids in E. coli overturns the clonality myth, and bacterial membrane vesicles as a novel strategy for extrusion of the antimicrobial bismuth in H. …

Mark Martin returns to TWiM to join the discussion of how to design a complex gut microbiome, and protection of protists from virus infection by intracellular bacterial symbionts.

Hosts: Vincent Raca…

TWiM reveals how to inactivate norovirus on formica surfaces, and how to achieve antibiotic resistance by suppression of a frameshift mutation in an essential gene.

Hosts: Vincent Racaniello, Michael…

TWiM explores the activation of natural product synthesis using CRISPR interference in Streptomyces, and how light/dark and temperature cycling modulate Electron Flow in Pseudomonas aeruginosa biofil…

TWiM presents a novel mucosal COVID-19 vaccine based on a bacteriophage capsid, and potentiation of C. difficile infection severity by the gut bacterial community.

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TWiM explores the use of Archaea to produce plastics from molasses wastewater, and a bacterial defense against bacteriophage infection that involves depletion of deoxynucleotides.

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TWiM reviews discovery of a bacterium that is visible to the naked eye, and reversible resistance to bacteriophage by shedding of the bacterial cell wall.

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TWiM discusses citizen science surveillance of drug-resistant Aspergillus in garden soil, and the mechanism of action of a copper dependent antibiotic.

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From ASM Microbe 2022 in Washington, DC, Heran joins TWiM to discuss her career and her work on the agent of tuberculosis, Mycobacterium tuberculosis.

Hosts: Vincent Racaniello, Michael Schmidt, and…

TWiM explains how spindle-shaped Archaeal viruses evolved from rod-shaped ancestors to package a larger genome, and transcriptional recording by CRISPR acquisition from RNA.

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TWiM explains the discovery of hotspots of genetic variation containing reservoirs of anti-phage systems in E. coli phages and their parasitic satellites, and pathogen desiccation tolerance promoted …

TWiM reveals that the atypical antipsychotic quetiapine promotes multiple antibiotic resistance in E. coli, and treatment with Bifidobacterium lactis probiotic benefits patients with coronary artery …

TWiM explains the use of lavender oil to disrupt Listeria biofilms, and how treatment of catheters with liquid silicone reduces associated urinary tract infections.

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TWiM welcomes new host Petra, and explains how a small protein helps ensure that E. coli utilizes a preferred carbon source, and a screening strategy to identify inhibitors of the type IV secretion s…

Mark returns to TWiM to join in a discussion of soil microbiota as game-changers in restoration of degraded lands, and discovery of a centimeter-long bacterium, the biggest yet discovered.

Guest: Mar…