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Preserving Muscle on GLP-1 Weight Loss Medications (or Rapid Fat Loss) | Ep 308

Author
Philip Pape, Evidence-Based Nutrition Coach & Fat Loss Expert
Published
Mon 14 Apr 2025
Episode Link
https://witsandweights.com/208

Get your free 15-minute Rapid Nutrition Assessment to identify your biggest nutrition challenge and get a personalized action plan to optimize your approach, whether you're considering GLP-1s, currently using them, or transitioning off (or go to witsandweights.com and click "Free Nutrition Audit")

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Millions of people are experiencing dramatic weight loss results with GLP-1 medications like Ozempic, Wegovy, and Mounjaro, but there's a catch that many doctors aren't discussing: without the right approach, up to 40% of that weight loss could be coming from muscle, not fat.

This episode gives you a blueprint for maximizing the benefits of these medications while protecting your metabolism, strength, and long-term results. 

Today I'm sharing practical, evidence-based strategies to preserve muscle while maximizing fat loss on these powerful appesite-suppressing medications, including how to adjust your nutrition, training, and lifestyle to maintain those results even after you stop.

Main Takeaways:

  • GLP-1 medications aid weight loss primarily through appetite suppression
  • Muscle loss isn't caused by the medications but by rapid weight loss without intervention
  • Resistance training and sufficient protein intake are non-negotiable for preserving muscle mass
  • Plan your transition off medication well in advance with a strategic approach

Episode Resources:

Timestamps: 

0:01 - Understanding GLP-1 medications and body composition
6:29 - Protein and nutrition strategies
10:14 - Micronutrients and tracking calories
12:10 - Why resistance training is essential
16:02 - Managing energy levels and strength training
16:47 - Planning for reducing or coming off GLP-1 medications
21:56 - Body recomposition


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