TWiV 860: Evading a Toll on the road to RNA vaccines

TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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• Vaccine Town Hall (ASV)
• Columbia University BSL-3 Manager position
• RNA modifications suppress innate recognition (Immunity)
• Critical contribution of pseudouridine (Front Cell Dev Biol)
• Rich Condit reminisces (YouTube)
• Letters read on TWiV 860
• Timestamps by Jolene. Thanks!

Dickson - NASA Research Launches a New Generation of Indoor Farming Kathy -How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral Rich - Fermi paradox Vincent - Racism not Race by Joe Graves

Jay – Restoration of Ave Maria John – Pandemic humor

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]