TWiV 742: De-fusing COVID-19

TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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• TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (Nature)
• Letters read on TWiV 742
• Timestamps by Jolene. Thanks!

Brianne – COVID-19: a disaster five years in the making Alan – The Tyranny of Merit Rich – Racism Makes Me Question Everything. I Got the Vaccine Anyway Kathy – The Transcontinental Burrito Tunnel Vincent – Trudy Rey’s YouTube Channel

Jeff – Rebecca Lee Smith on Left Right and Center Ryan – Perfect Strangers (clip)

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]