TWiV 351: The dengue code

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.

• Paula Pitha-Rowe (Balt Sun)


• Novel poxvirus (CID)


• H1N1 and gain-of-function debate (mBio)


• Recoding dengue virus genome (PNAS)


• Attenuation by dinucleotide frequency change (PNAS)


• Codon pair and dinucleotide bias not distinguished (PNAS)


• Codon pair deoptimization artefact of CG/UA change (eLife)


• Can engineering subdue viral vaccine reversion? (Virus Evol)


• Attenuation by a thousand cuts (NEJM)


• Image credit


• Letters read on TWiV 351

Alan - Genetic roulette Rich - The Huntington Kathy - Simulated vomiting machine (video) Dickson - Last Cassini Saturn flybyVincent - Decaying Still Life (YouTube)

Ken - Cave meterology (Times, Nature)

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