Genetic Pathways to Longevity: Harnessing Polygenic Risk Scores for Personalized Age-less Interventions

Dive into polygenic risk scores (PRS) and discover how your genetic blueprint can inform personalized longevity strategies. Dr. Ethan Hausman-Marquis breaks down genome sequencing, five major genetic pathways to aging (DNA repair, metabolism, inflammation, mitochondria, neurodegeneration), and real-world clinical applications from The Catalyst Clinic.

Learn how PRS can shift prevention from one-size-fits-all to truly individualized interventions—while understanding limits like population bias and probabilistic risk. Perfect for longevity science fans curious about precision medicine, NAD+, peptides, and building cognitive and mitochondrial resilience. If this episode helped you, please like and share with someone interested in age-less living. #PolygenicRiskScore #Longevity #PrecisionMedicine #AntiAging #Genomics

OUTLINE:

00:00:00 Title and Introduction

00:02:35 Genes Aren't Destiny

00:06:19 What Is a Polygenic Risk Score?

00:10:28 Two Patients Example

00:13:17 Five Major Pathways

00:20:58 Limitations and Caveats

00:25:30 Clinical Application

00:27:56 Emotional Impact

00:29:58 Closing Reflection