Mini Episode: Bridging the Gap- Bupropion's not your average wide QRS with Dr. Travis Olives
- Author
- Clinical Toxicology LLC
- Published
- Wed 15 Feb 2023
- Episode Link
- https://thepoisonlab.com/episode/mini-episode-bridging-the-gap-bupropions-not-your-average-wide-qrs-with-dr-travis-olives
- Rohr 2004- Gap junction blockade can cause a wide QRS
- Vink 2004 Connexin 43 is the most important protein for connexon formation and cardiac signal transmission
- Callier 2012- Bupropion does not block sodium channels, and does exhibit similar effects on the cardiac action potential as known gap junction
- Burnham 2014 Bupropion has an IC50 for connexin 43 >50 uMol, larger than other drugs such as fluoextine and lamotrigine
- Shaikh Quereshi 2014 Bupropion interferes with connexin43 production and localization in chicken cardiac myoctes at concentration >50 uMol
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