Episode 016 - Butyrate: The Most Underrated Molecule in Human Health

Butyrate might be the most underrated molecule in human health.

In this episode, Brandon explains how butyrate stabilizes signals across the gut–liver axis, mitochondria, and immune tone—why many people don’t feel much from older forms—and how improved bioavailability changes outcomes.

You’ll learn:

• What butyrate does (gut barrier, immune calibration, mitochondrial support, redox balance)

• Endogenous vs. supplemental butyrate—and where each shines

• Practical use cases: cravings, energy stability, mood, sleep architecture, exercise recovery

• Forms & bioavailability: 2024 PK data comparing sodium butyrate, spray‑dried tributyrin, and BIOMEnd® (tributyrin performed ~5× worse than BIOMEnd® in that study; no coated/time‑release butyrate was included)

• How to integrate butyrate into a daily stack without overwhelm

🎯 Take the Drift Quiz: https://www.themetaboliccompass.com/quiz

➡️ Next: Episode 017 — Why Morning Light May Be the Most Powerful Hormone Reset Tool You’re Ignoring