Dr. Jordan and Dr. Williams discuss GLP-1 drugs like Ozempic and semaglutide, highlighting their role in weight loss by mimicking glucagon, which regulates sugar and appetite. These drugs slow stomach emptying, reducing hunger and cravings, but can cause nausea and constipation in 50% of users. They often lead to weight loss, but 25% of the weight lost is lean body mass, resulting in a "Hollywood look." Long-term use may cause thyroid issues and gastrointestinal side effects. Billings Last Diet offers a program to support GLP-1 users with proper nutrition, protein intake, and lifestyle coaching to ensure sustainable weight loss and prevent regain.