Ep. 20: “Mucosal Immunology” Featuring Dr. De’Broski Herbert

Guest:

Dr. De’Broski Herbert is an Associate Professor of Immunology at the University of Pennsylvania. The Herbert lab is exploring the immunoregulatory and regenerative mechanisms operating at the mucosal interface. He discusses his recent paper on IL-33 sources and secretion, his postdoctoral fellowship in South Africa, and the M1/M2 macrophage paradigm.

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The Immunology Science Round Up

TREM-2 and T Cells in SARS-CoV-2 – Researchers showed that triggering receptor expressed on myeloid cells 2 (TREM-2) expression was increased on T cells in patients with COVID-19.

Neutralizing the Omicron Variant – mRNA vaccine boosters may increase SARS-CoV-2 neutralizing antibody titers.

T Cells Still Recognize the Omicron Variant – Early data suggest that existing CD8⁺ T cell responses from previous SARS-CoV-2 infection or vaccination will likely recognize the Omicron variant of concern.

A Nasal Vaccine for Influenza – An intranasal flu vaccine enhanced immunoglobulin A responses through lung-resident memory B cells, plasmablasts, and plasma cells in mice.

Mucosal Antibody Responses to SARS-CoV-2 Vaccination – Mucosal immunoglobulin A responses to mRNA vaccination depend on pre-existing immunity.

An Alternative Approach for Anthrax – Scientists used capsule depolymerase to remove the Bacillus anthracis bacterial capsule and promote phagocytosis and killing by human neutrophils.

Image courtesy of Dr. De’Broski Herbert