Episode 17 – GLP-1 in Type 1 Diabetes: beyond weight loss, towards metabolic therapy?

Guest: Prof. Viral Shah

Host: John Pemberton of The Glucose Never Lies

Description:
GLP-1 and GIP therapies are transforming type 2 diabetes and obesity care. But what about type 1 diabetes?

In this episode, I speak with Professor Viral Shah — a leading clinician–researcher in type 1 diabetes, automated insulin delivery, and incretin therapies. Together we explore:

• Why people with type 1 diabetes face unique metabolic challenges (peripheral insulin delivery, insulin resistance, excess glucagon).
• How GLP-1/GIP therapies may help reduce insulin needs, manage weight, smooth post-meal highs, and improve long-term outcomes.
• The latest evidence from trials in type 1 diabetes and what’s on the horizon with dual and triple agonists.
• Practical questions for people with T1D and healthcare professionals: insulin adjustment, titration, safety, and off-label prescribing.

🔗 Episode show notes & links:
https://theglucoseneverlies.com/glp1-t1d/

🌐 Key Links

The Glucose Never Lies®:

• Website → https://theglucoseneverlies.com/
  
  
• YouTube → https://youtube.com/c/TheGlucoseNeverLies
  
  
• Spotify → https://open.spotify.com/show/2MlGlz2G8LsbDnuGtAh77W
  
  
• Apple Podcasts → https://podcasts.apple.com/gb/podcast/the-glucose-never-lies/id1795741144
  
  
• Buzzsprout → https://www.buzzsprout.com/2451357
  
  

Viral Shah:

• ResearchGate → https://www.researchgate.net/profile/Viral-Shah
  
  
• PubMed search → https://pubmed.ncbi.nlm.nih.gov/?term=Shah+VN+GLP-1
  
  
• Indiana University School of Medicine Profile → https://medicine.iu.edu/faculty/5109/shah-viral
  
  

Background Reading (GNL):

• Overcoming Insulin Resistance in T1D → https://theglucoseneverlies.com/overcoming-insulin-resistance-t1d/
  
  
• Eight Causes of Insulin Resistance → https://theglucoseneverlies.com/eight-casues-insulin-resistance/
  
  
• Seven Ways to Combat Insulin Resistance → https://theglucoseneverlies.com/seven-ways-combat-insulin-resistance
•  Episode 14: Overcoming Insulin Resistance in Type 1 Diabetes/ → https://theglucoseneverlies.com/14-type-1-diabetes-insulin-resistance/

Enjoy