Cell rejuvenation – Resetting the biological clock

Aging is a dynamic process characterized by the accumulation of cell damage, tissue, and organ degeneration, and diminished function. This process of decline appears to be an inevitable aspect of human existence. In recent years, however, advancements in scientific understanding of aging bring us closer to extending the human lifespan.
With their guests, Dr. Jürgen Reess and Prof. Hartmut Geiger, founders of Moglingbio, Louise von Stechow and Andreas Horchler explore the complex science underlying the process of aging and the challenges faced by the budding longevity industry. They talk about the potential for rejuvenating aged cells in human tissues and the ethical considerations of extending the human lifespan.

Content and Editing:
Louise von Stechow and Andreas Horchler

Disclaimer:
Louise von Stechow & Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics, but do not claim to give medical, investment or even life advice in the podcast.

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Image:
Marcelo Leal via Unsplash

References:
Theories and Hallmarks of Aging

1. https://www.afar.org/imported/AFAR_INFOAGING_GUIDE_THEORIES_OF_AGING_2016.pdf


2. https://www.nature.com/scitable/knowledge/library/the-evolution-of-aging-23651151/


3. https://www.nature.com/articles/s41576-022-00513-5


4. https://www.cell.com/fulltext/S0092-8674(13)00645-4


5. https://www.nature.com/articles/s43587-022-00335-4


6. https://www.nytimes.com/2021/04/27/magazine/global-life-span.html

Life-prolonging treatments and Cell Rejuvenation

1. https://www.science.org/content/article/feature-man-who-wants-beat-back-aging


2. https://www.nature.com/articles/s43587-023-00416-y


3. https://www.nature.com/articles/s41586-021-04282-9


4. https://dogagingproject.org/triad


5. https://www.dvcstem.com/post/anti-aging-stem-cells


6. https://www.mayoclinic.org/tests-procedures/bone-marrow-transplant/in-depth/stem-cells/art-20048117


7. https://www.fda.gov/consumers/consumer-updates/fda-warns-about-stem-cell-therapies


8. https://pubmed.ncbi.nlm.nih.gov/27286740/


9. https://www.nature.com/articles/s41392-023-01343-5


10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023768/


11. https://pubmed.ncbi.nlm.nih.gov/35859206/


12. https://www.nature.com/articles/s41536-022-00275-y


13. https://www.nature.com/articles/s43587-023-00528-5


14. https://www.nature.com/articles/s41591-022-01923-y


15. https://www.nature.com/articles/s43587-023-00373-6

The longevity industry

1. https://www2.deloitte.com/us/en/pages/life-sciences-and-health-care/articles/longevity-science.html


2. https://www.forbes.com/sites/forbestechcouncil/2021/05/03/will-you-live-to-200-five-levels-of-breakthroughs-in-longevity-research-you-must-know-about/


3. https://www.theguardian.com/books/2022/may/02/could-we-make-aging-a-thing-of-the-past


4. https://longevity.technology/news/unity-cuts-lead-program-after-clinical-trial-fail/


5. https://longevity.technology/news/global-longevity-investment-hit-5-2-billion-in-2022/


6. https://www.nature.com/articles/d41587-022-00002-4


7. https://www.forbes.com/sites/alexzhavoronkov/2023/09/16/what-is-a-longevity-biotechnology-company/?sh=4d4ac9a7702a


8. https://venturebeat.com/business/the-brains-behind-calico-bill-maris-of-google-ventures/


9. https://spannr.com/articles/longevity-industry-introduction#:~:text=What%20is%20the%20longevity%20industry%3F%20The%20longevity%20industry,promote%20healthy%20aging%20and%20improve%20quality%20of%20life.


10. https://edition.cnn.com/2013/10/03/tech/innovation/google-calico-aging-death/index.html