Episode 7: Double, Double, Toil and Trouble Pt. 1

There is a constant discourse between herbalist and the scientific community...neither of which seem to see the side of another, but is there a place for herbalism within healing? Hosts Astra, Hanne, and Fel discuss what herbalism is and the place they feel is should occupy within the scientific world of drug development. What are the benefits and limitations of herbalism vs. synthetics? Fair warning, this episode goes deep into some science, but it's fascinating stuff!

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Resources:

Derivation of drugs from natural products (NPs) and current screening methods:

The Story of Aspirin: https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.14520

NPs as a Source for Drug Design: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560124/

Review of the role of NP in Drug Design: https://www.nature.com/articles/nrd1657

A Historical Overview of NP in Drug Design: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901206/#B30-metabolites-02-00303

NP in Drug Design: Advances and Opportunities: https://www.nature.com/articles/s41573-020-00114-z

Dried-leaf Artemesia annua: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323188/

Whole Plan Artemesia annua as antimalarial therapy: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052746

Molecular Mechanism of Thalidomide: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281272/

Psychedelics being re-engineered for clinical therapeutics: https://www.nature.com/articles/d41586-020-03404-z

Drug Discovery Process

Stages of Drug Discovery: https://www.researchgate.net/publication/341097009

Drug Discovery and Development - A story: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725284/