The Stress-Inflammation Connection: How Chronic Stress Shapes Depression

Chronic stress is more than just feeling overwhelmed—it reshapes the brain and body in ways that can directly contribute to depression. In this episode of Strides to Solutions, Esther Adams unpacks the latest research on how stress triggers neuroinflammation, alters brain regions tied to mood and memory, and disrupts key neurotransmitter systems.

Listeners will learn:

* How the body’s stress-response system becomes dysregulated under chronic stress

* The role of inflammatory molecules and microglia in fueling depression

* Why the hippocampus and prefrontal cortex are especially vulnerable

* Protective factors like social support and resilience that buffer against stress

* Emerging treatments targeting inflammation and brain health

This episode highlights both the science and the hope—showing how managing stress is not just about short-term relief, but about protecting long-term mental health.