Jill Herschleb on Discovery-Based Research with Single-Cell Genomics

Episode #8.

Jill Herschleb, senior director of cell biology at 10x Genomics, talks about her path as a scientist and her work in building the tools that have helped make single-cell genomics the robust and flexible technology it is today. 

Here is an informative video on single cell genomics and its use in the effort to make a comprehensive human cell map (aka, the Human Cell Atlas). 

In Part 1 of this conversation, we discuss:

*How Jill got interested in science as a kid [2:30]

*Jill’s grad school realization that scientists could build tools, and that was what she wanted to focus on [4:15]

*Jill’s path after graduate school, and the many opportunities for scientists beyond academia [6:05]

*Jill’s role at 10x Genomics [10:15]

*Prelude to single-cell genomics: next-generation sequencing (NGS). What is it and why it is important? [14:20]

*How did NGS lead to single-cell genomics? What is single-cell genomics? Moving beyond the limits of hypothesis-based research with single-cell genomics [18:45]

*One example of an important discovery from single-cell genomics: the pulmonary ionocyte and its role in Cystic Fibrosis [28:00]

*The necessity of more data at this resolution — the single cell — to make important discoveries [32:30]

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