Treatment Contraindications

You are evaluating a 71-year-old female patient and have made a diagnosis of major depressive episode, moderate. The patient is agreeable to pharmacotherapy. When considering pharmacologic treatment options, you review her existing medication list for potential interactions and contraindications. Which of the following classes of medication might increase the patient’s risk of cognitive impairment with the addition of an SSRI?

A. A calcium channel blocker

B. An antiepileptic

C. A diuretic

D. A proton pump inhibitor
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