The Liver as a Central Hub of the Immune System

In the episode, Dr. Mark Donowitz (Johns Hopkins School of Medicine) interviews Dr. Pietro Invernizzi (IRCCS Fondazione San Gerardo dei Tintori; University of Milano-Bicocca) and Dr. Vincenzo Ronca (University of Birmingham; Humanitas University) about their recent Review article that describes the immune function of the liver. Listen as these experts discuss immune tolerance in the liver, sex differences related to this immune tolerance, as well as new technological developments applied to the current understanding of immunology in the liver. This engaging conversation offers insights into both autoimmune liver diseases and non-autoimmune liver diseases, and glances toward the future for the “next big thing” advancing the field. To find out more, listen now.

Vincenzo Ronca, Alessio Gerussi, Paul Collins, Alessandro Parente, Ye Htun Oo, and Pietro Invernizzi The liver as a central “hub” of the immune system: pathophysiological implications Physiological Reviews, published January 15, 2025. DOI: 10.1152/physrev.00004.2023