NFL Week 1 DraftKings Picks 2025 | Best DFS Lineups, Ownership & Pick’em Plays

NFL is back! In this video, Pat Mayo, Tyler Tamboline and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 1 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 1. Whether you’re entering GPPs or cash games, this guide has you covered.

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Show Index

00:00 Intro

00:41 TNF Takeaways

16:51 Week 1 DK Main Slate Overview

19:27 Optimal + CLE/CIN

42:11 MIA/IND

54:05 DEN Stack

59:51 WAS/NYG

1:07:46 ARZ/NO

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