63. Advanced Grade 3 Neuroendocrine Tumours - Chemotherapy options

Neuroendocrine Tumours could be described as an impassable obstacle, more complicated the more you research. That's where Michael and Josh come in, and this week, explore Grade 3 metastatic neuroendocrine tumours. Michael provides a brilliant overview of this well-differentiated cohort and the lack of efficacy platinum chemotherapies have, while Josh discusses CAPTEM (temozolomide and capecitabine) through a systematic review. Interestingly many of the current data is retrospectively collected, highlighting how challenging it is to collect enough patients to pursue meaningful research.

Note- there is a quote from Lance Armstrong, who was stripped of his titles due to illegal doping (which we do not endorse); he did start the Livestrong Foundation to support those affected by cancer.

Links to studies discussed in this episode (subscription may be required):

1. Review - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158108/

2. Cape/tem - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790144/

3. Platinum-based chemo: https://erc.bioscientifica.com/view/journals/erc/20/5/649.xml

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Art courtesy of Taryn Silver

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