The episode provides an analysis of Paracelsus's Paragranum, a work in which the author seeks to reform traditional medicine based on a new vision of the world. Paracelsus (Theophrastus Bombastus von Hohenheim, 1493-1541) criticizes the doctors of his time, accusing them of following outdated methods and of not understanding the true nature of diseases. He argues that medicine must be based on the observation of nature and on alchemy, which he sees as a means to achieve the perfection of the microcosm, man, through his interaction with the macrocosm. In essence, Paracelsus's work represents an attempt to establish a new medicine on philosophical and experimental bases, overcoming traditional theories and paving the way for a more complex and holistic vision of the relationship between man and nature.