In patients with multiple sclerosis, lesions in white matter can disrupt brain connectivity, leading to cognitive and motor impairments. Join Dr. Amy Kuceyeski as she discusses the pathophysiology behind structural disconnectivity and shares insights on new tools being developed to more accurately identify it in patients with multiple sclerosis. Dr. Kuceyeski is a Professor of Mathematics in Radiology and Neuroscience at Weill Cornell Medicine, and she spoke on this topic at the ACTRIMS Forum 2025.