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From Stress to Strength: How to Rewire Your Brain with Jamey Maniscalco

Author
Diksha
Published
Wed 02 Jul 2025
Episode Link
https://mindovermatterr.podbean.com/e/from-stress-to-strength-how-to-rewire-your-brain-with-jamey-maniscalco/

In this transformative episode of Mind Over Matter, neuroscientist and Manifest Wellness founder Jamey Maniscalco breaks down why stress isn’t the villain we’ve made it out to be. With over a decade studying stress and the brain, Jamey shares how your mindset about stress—more than the stress itself—can affect your health, decision-making, and longevity. Learn about the science behind stress hormones like cortisol and DHEA, how to shift into a “stress-is-enhancing” mindset, and three actionable tools to stop mental rumination in its tracks. Whether you’re battling anxiety or looking to optimize your performance, this episode delivers brain-backed strategies for lasting change.


About the Guest:

Jamey Maniscalco is a neuroscientist, professor, and founder of Manifest Wellness Co., a platform helping individuals build sustainable wellness habits rooted in neuroscience. With a background in stress physiology and behavioral health, she bridges science with practical tools to empower personal transformation. Jamey is on a mission to make complex science actionable and accessible for everyone.


Key Takeaways:




  • A “stress-is-enhancing” mindset can increase resilience, reduce anxiety, and even lower mortality risk.




  • Stress hormones like DHEA can boost brain growth and emotional stability—when harnessed correctly.




  • Simple practices like mindfulness, exercise, and quality sleep support a healthier stress response.




  • Reframing stress, identifying its purpose, and recognizing its growth potential are keys to mental mastery.




  • Rumination is a brain loop we can disrupt through de-catastrophizing, journaling, and reclaiming control.




Connect with Jamey Maniscalco:



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