#18 Aubrey de Grey | The Big 2025 Interview

In this in-depth conversation, Dr. Aubrey de Grey discusses his Robust Mouse Rejuvenation (RMR) studies at the LEV Foundation and why he believes we're close to achieving the crucial RMR milestone within just three years - a breakthrough that could transform aging research forever.

You'll also hear about:

His predictions for reaching Longevity Escape Velocity by the late 2030s

What he would change about Bryan Johnson's longevity algorithm

How reaching RMR could trigger a global "war on aging"

Why AI won't solve aging without proper experimental data

How Demis Hassabis is the smartest person Aubrey's ever met

His involvement in designing the XPRIZE Healthspan competition

His rebuttal to Mark Hamalainen's "replacement strategy" approach

The divide-and-conquer approach to aging and why it's superior

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-- CHAPTERS --

00:00 Introduction and Welcome

03:15 The Background to LEV Foundation and the Robust Mouse Rejuvenation Studies

12:05 The Robust Mouse Rejuvenation Studies

18:10 Latest Results from the Mouse Rejuvenation Experiments

25:42 Reaching RMR soon and LEV in 12-15 years

33:47 Healthspanners in public - lifespanners in private?

37:03 The Replacement Strategy Debate with Mark Hamalainen

45:40 The Very, Very Difficult Challenge of Gradually Replacing the Brain

54:46 Advanced bioengineering

57:34 The Debate with Peter Fedichev

01:11:57 Understanding Aging from an Evolutionary Perspective

01:17:05 Artificial Intelligence and Longevity Research

01:26:42 Is believing in AI hopium?

1:28:27 Aubrey’s Involvement in the XPRIZE Healthspan Competition

1:38:56 Special Economic Zones and Regulatory Challenges

1:47:27 What Aubrey would do with Bryan Johnson’s algorithm

1:50:49 What Excites Aubrey Most About the Future

1:51:57 Book Recommendations and Closing Thoughts

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