“30 Days of Retatrutide” by Brendan Long

I've had trouble maintaining my weight since high school. If I eat "normally", I slowly gain weight, and if I eat nothing but a specific potato casserole, I slowly lose weight.

Recently, I hit a new high-record weight and decided it was finally time to do something more serious about it, so for the last month I've been taking the standard CICO diet advice. I finally realized that I should eat healthier, and eat significantly less. I work out slightly more. I cut out most high-fat foods and became strict about not eating after 6 pm.

Anyway, this is a post about my experience with retatrutide.

This is not a how-to article, so I'm not going to talk about where to get peptides or how to safely use them. See this article if you're into that sort of thing.

The Experiment

Retatrutide is a GLP-1 agonist similar to semaglutide [...]

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Outline:

(00:58) The Experiment

(02:01) Effects

(03:20) Side Effects

(03:24) Muscle Loss?

(03:59) Heartburn

(04:40) Heart Rate

(05:13) Skin Sensitivity

(05:29) Chills

(06:04) Injection Site Redness

(06:32) Splitting Doses

(06:54) Other Effects

(07:58) A Theory

(08:35) Final Thoughts

The original text contained 1 footnote which was omitted from this narration.

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First published:

September 4th, 2025

Source:

https://www.lesswrong.com/posts/mLvek6a9G86EnhJqH/30-days-of-retatrutide

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Narrated by TYPE III AUDIO.

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