The Shape of Life: 2024 Nobel Prize in Chemistry and the AlphaFold Revolution

This episode unpacks why the 2024 Nobel Prize in Chemistry matters for biology and medicine, from the protein folding problem to the AI-driven breakthroughs of AlphaFold. We trace the prize winners—David Baker for protein design and Demis Hassabis and John Jumper for AlphaFold—and explain how AlphaFold 2 and 3 are transforming drug discovery, enzyme engineering, and our understanding of diseases linked to misfolded proteins. We also discuss current limits, such as predicting protein interactions in complexes, and what’s next for science and society.

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