CD Decode: Reading Biomolecular Shapes with Circular Dichroism

We demystify circular dichroism (CD) — a fast, non-destructive probe of biomolecular structure. This episode explains how differential absorption of left and right circularly polarized light reveals protein secondary structure, nucleic acid forms, and interactions, covers practical prep and instrument basics, touches on advanced methods like SRCD, and discusses limitations and how CD complements high-resolution techniques in accelerating discovery.

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