Unlocking the Longevity Secrets of Man’s Best Friend

Our guest today is Matt Kaeberlein, Ph.D., a globally recognized researcher and expert in the biology of aging. Dr. Kaeberlein’s research is based around the premise that understanding the molecular mechanisms of aging will lead to interventions that slow the onset and progression of age-related chronic conditions, such as cancer, diabetes, kidney disease, heart disease, Alzheimer’s and others. Dr. Kaeberlein received his Ph.D. from the Massachusetts Institute of Technology in 2002 advised by Leonard Guarente, and did his post-doctoral work with Stanley Fields in the Department of Genome Sciences at the University of Washington.

Dr. Kaeberlein’s expertise in dietary restriction, longevity genes for therapeutics, aging in dogs, and Rapamycin really shines in this conversation. We were lucky enough to really explore his background while sharing our collective love of dogs. The conversation explores many areas, including:

• What is the difference between calories restriction and dietary restriction
• What are the biggest challenges with the science
• How Matt thinks about tailored dietary advice
• Why Matt launched the Dog Aging Project
• What we can learn from his research with dogs
• What is Rapamycin and why he’s so interested in its effects

This conversation was incredibly illuminating and really fun. We hope you enjoy the episode and share it with your friends, family, and colleagues.

• Matt Kaeberlein
• Matt Kaeberlein Twitter

• Next Generation sequences
• Metabolomics
• Epigenetic clocks
• Calorie Restriction Society
• TAME Trial
• Rapamycin
• Daniel Promislow
• Dog Aging Project
• Acarbose
• NIA Interventions Testing Program
• Shock center of excellence
• George M. Martin
• Rapalog Everolimus