Why are big-name investors holding back this spring

In April 2025, startup funding decreased as major investors reduced their activity. Andreessen Horowitz led with 13 deals, including a $200 million Series B for Base Power and over $100 million for residential real estate startup Flow, co-founded by Adam Neumann. Khosla Ventures followed with 10 deals, notably investing in a $104 million round for biotech firm Science and substantial funding for Cyberhaven and Mainspring Energy. General Catalyst participated in 9 deals, marking a slowdown from the previous months. BoxGroup and Index Ventures each completed 8 deals, while Ocampo Capital led 7. Greenoaks Capital Partners coordinated the largest rounds, including a $2 billion investment in Safe Superintelligence. Y Combinator remained the most active incubator, funding 22 startups. The analysis includes U.S.-based investors and excludes variable incubator or accelerator activities.

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