The quote from this episode is:
Twenty years from now you will be more disappointed by the things you didn’t do, than by the things you did.
Brian talks about how one of his major regrets in life is not having attempted the Appalachian Trail. Something that he has always wanted to tackle, and just might after calling himself out on this episode. Patrick talks about how valuable it could be to experience the world with the "eyes of a child"...meaning, that you see the world as a playground with no limitations and no repercussions to attempting everything you want to do.