Deep Dive MW R22

Guillain-Barre Syndrome (GBS) – Autoimmune polyneuropathy that results in widespread demylination of peripheral nerves











Typically occur 1 week after a triggering infection











Paresthesias/Neuropathic Pain -> Ascending symmetric paralysis -> Respiratory Failure











Major Diagnostic Criteria














* Progressive limb weakness in multiple limbs that is relatively symmetric











* Diminished/Absent deep tendon reflexes in affected limbs











* No alternative diagnosis











* CSF studies have false-negatives – May see albuminocytologic dissociation (Elevated protein with normal cell counts)














Treatment – IVIG and monitor respiratory status