Channel Your Enthusiasm

References

Part 2, March 1, 2023

The alkaline tide phenomenon in studies that measured both the alkaline tide and acid secretion, the bicarbonate accumulation increased in linear fashion with the acid …

References

Chapter 19, Part 1 

Metabolic acidosis  June 14, 2023

American Society of Nephrology | Medical Students - Kidney TREKS this is the program that Josh mentioned at Mount Desert Island! 

Effects …

We are a bit slappy at the beginning of the episode since we had just recorded our conversation with the Glaucomfleckens.

References

Chapter 18 Metabolic alkalosis! 

Part 1 February 23, 2023

It is chlor…

References

I said I used MDCalc but I was mistaken I use MedCalX which is nice but getting dated. 

We talked about this out of print book that we love: Cohen, J. J., Kassirer, J. P. (1982). Acid-base. …

References

We talked about winning the 2022 ASN innovation contest and here’s a link to our promo video https://www.dropbox.com/scl/fi/g4osnf0nradsfryyo51fi/ASN-Education-Contest-Channel-Your-Enthusia…

References

Capillary Hemodynamics  Insights into Salt Handling and Blood Pressure | NEJM

Amy mentioned about the 3 phases of the interstitium

Are the precapillary sphincters and metarterioles universal …

References

Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice Melanie is in love with this paper that show…

Outline Chapter 15 — Clinical Use of Diuretics

- Among most commonly used drugs

- Block NaCl reabsorption at different sites along the nephron

- The ability to induce negative balance has made them usef…

Outline Chapter 14 — Treatment

- Treatment

- Both oral and IV treatment can be used for volume replacement

- The goal of therapy are to restore normovolemia

- And to correct a…

Outline

Chapter 14

- Hypovolemic States

- Etiology

- True volume depletion occurs when fluid is lost from from the extracellular fluid at a rate exceeding intake

- Can come the GI tract

…

References

JC mentioned that the diagnostic accuracy of 24 hour urine collection increases with more collections! Metabolic evaluation of patients with recurrent idiopathic calcium nephrolithiasis

We d…

References

We considered the complexity of the machinery to excrete ammonium in the context of research on dietary protein and how high protein intake may increase glomerular pressure and contribute t…

The Channelers went where no nephrology podcasters have gone before, recording in front of a live audience at the National Kidney Foundation Clinical Meeting in Austin. We had all eight Channelers do…

References

We considered the effect of a high protein diet and potential metabolic acidosis on kidney function. This review is of interest by Donald Wesson, a champion for addressing this issue and li…

References for Chapter 10

We did not mention many references in our discussion today but our listeners may enjoy some of the references below. 

Effects of pH on Potassium: New Explanations for Old Obse…

References for Chapter 9

One of the few papers that Rose wrote as a single author explores electrolyte free water clearance. This seminal paper explores the issue in greater detail than the book. A Ne…

References for chapter 8

Robert Schrier proposed a unifying hypothesis to explain the sodium retention seen in edematous states like cirrhosis and heart failure, coining the term effective arterial bl…

Chapter 7

References

Sands JM, Blount MA and Klein JD. Regulation of Renal Urea Transport by Vasopressin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116377/

In this invited piece, Sands and colleague…

Chapter 6 part 2.

References

Josh touts the PARADIGM-HF Trial Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure | NEJM which found this combination was superior to an ARB alone 

Joel …