This episode of Chain Reaction covers the CoinDesk Twenty performance with Internet Computer surging over twenty percent and emerging ETF trends as Ethereum funds record inflows while Bitcoin ETFs see outflows. We discuss MicroStrategy added over one thousand Bitcoin and how US China trade talks lifted Solana and the Hang Seng. Highlights include custody concerns at Coinbase and Pi Network mainnet, Cetus Protocol making a comeback after a massive exploit, and major capital moves by Turnkey, OpenLedger and The Blockchain Group. We also explore NFT and gaming updates from OpenSea and Bonk Arena, legislation on a strategic Bitcoin reserve and accreditation rules, and technical outlooks for Shiba Inu, XRP and Dogecoin.