The FLO8 Breakthrough: A New Era for Methanol-Free Protein Production in Komagataella phaffii
- Author
- This podcasts have been AI generated.
- Published
- Sun 03 Aug 2025
- Episode Link
- https://podcasters.spotify.com/pod/show/science-communication-at-/episodes/The-FLO8-Breakthrough-A-New-Era-for-Methanol-Free-Protein-Production-in-Komagataella-phaffii-e36cj4o
Flo8 knockout in Komagataella phaffii prevents pseudohyphal growth and reduces adherence. This study reveals it significantly elevates glucose-regulatable promoter activity, boosting recombinant protein yields up to 7-fold. This new host strain offers higher productivity per gene copy and improved process robustness for methanol-free bioproduction.
