The pyridoxal phosphate contribution to amino acid metabolism and neurotransmitter turnover Dr Guerra Authentic Biochemistry 10 March 2021
- Author
- Dr Daniel J. Guerra
- Published
- Thu 11 Mar 2021
- Episode Link
- https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/episodes/The-pyridoxal-phosphate-contribution-to-amino-acid-metabolism-and-neurotransmitter-turnover-Dr-Guerra-Authentic-Biochemistry-10-March-2021-es818j
If γ-aminobutyric acid (GABA) concentration drops significantly in the synaptic cleft, excitotoxicity can obtain, sometimes presenting with epileptic convulsions.This can be reversed by decreasing the concentration of L-glutamate via control over the activity of glutamate dehydrogenase, glutamine synthetase and glutamate transporters or by the inhibition of γ-aminobutyric acid aminotransferase (GABA-AT), which catalyzes the conversion of GABA to the excitatory neurotransmitter l-glutamic acid.
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