Senescence and Aging Relative to T lymphocytes may be linked to chemotherapy of testicular cancer and underlying cell cycle-CD transcriptional mutations.

Dr Guerra continues his associative pathobiochemical dialectic concerning T lymphocytte differentaition and senescence

The  Th and Tc populations following uptake and processing of an antigen by an APC such as a dendritic cell is presented either to the CD8 population in the context of MHC-I or to the CD4 subpopulation in the context of MHC-II generates a cascading set of cellular lymphoproliferative and differentiative steps initiated under the inductive influence of cytokines that ultimately determine  effector functions.

Papers examined in this episode:

Nat Med. 2017 Jun; 23(6): 775–781

Cancer Genet Cytogenet. 1999 Mar;109(2):108-13.

BMC Cancer volume 20, Article number: 882 (2020)