Natural Killer Cell switching via demethylation of Histone 3 LYS may correlate with the human aging phenotypic hyper-inflammatory state. DJGPhD. 28.9.21
- Author
- Dr Daniel J. Guerra
- Published
- Tue 28 Sep 2021
- Episode Link
- https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/episodes/Natural-Killer-Cell-switching-via-demethylation-of-Histone-3-LYS-may-correlate-with-the-human-aging-phenotypic-hyper-inflammatory-state--DJGPhD--28-9-21-e181eql
Pro-inflammatory gene transcription is tanked when demethylation is inhibited but cytotoxicity of virally infected or cancer cells by NK’s (where demethylation is inhibited) remains intact.
References
J. Biol. Chem. 2018;293:2422-2437
J. of Biol. Chem. 2016. 291, 23756-23768
