Natural cytotoxicity receptors (NCR's) within group 3 innate lymphoid cells (ILC3): an association of transcription factors in IBD's and aging. DJGPhD. 03.10.21 Authentic Biochemistry.

ILC3 can contribute to the progression and aggravation of IBD's while both IL-22 and IL-17, along with IFN-γ, are overexpressed by the dysregulation of NCR− ILC3 or NCR+ ILC3 function

NCR (natural cytotoxicity receptors), are  type 1 transmembrane proteins of the immunoglobulin superfamily. Upon stimulation, NCR's mediate NK killing and release of IFNγ. They bind viral ligands such as hemagglutinins, neuraminidases,  bacterial ligands, and cellular ligands related with auto immune diseases, tumour growth, and associated aging morbidity.

References

Experimental & Molecular Medicine volume 51, Article number: 80 (2019)

Cell Death & Disease volume 10, Article number: 315 (2019)

Front. Immunol., 28 September 2015