Microglial TLR activation mediates Aging-Associated CNS Neurodegeneration. Dr. Daniel Guerra. Authentic Biochemistry Podcast. 13 May 2021.
- Author
- Dr Daniel J. Guerra
- Published
- Fri 14 May 2021
- Episode Link
- https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/episodes/Microglial-TLR-activation-mediates-Aging-Associated-CNS-Neurodegeneration--Dr--Daniel-Guerra--Authentic-Biochemistry-Podcast--13-May-2021-e10raq5
TLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling.
TLR interactions from CNS-resident microglia can obtain a pro-inflammatory environment that leads to neuronal degeneration as associated with classical aging related diseases like Parkinson's.
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